Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases

Versión final del documento embargada hasta 2081-08 por política editorial

Detalles Bibliográficos
Autores: Escalante Muñoz, Teresa, Rucavado Romero, Alexandra, Fox, Jay W., Gutiérrez, José María
Tipo de recurso: artículo
Fecha de publicación:2011
País:Costa Rica
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/29556
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S187439191100128X
https://hdl.handle.net/10669/29556
http://dx.doi.org/10.1016/j.jprot.2011.03.026
Access Level:acceso embargado
Palabra clave:Snake venom
Metalloproteinases
Hemorrhage
Capillary vessels
Basement membrane
Disintegrin-like domain
Cysteine-rich domain
Collagens
Perlecan
Nidogen
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dc.title.es_ES.fl_str_mv Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
title Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
spellingShingle Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
Escalante Muñoz, Teresa
Snake venom
Metalloproteinases
Hemorrhage
Capillary vessels
Basement membrane
Disintegrin-like domain
Cysteine-rich domain
Collagens
Perlecan
Nidogen
title_short Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
title_full Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
title_fullStr Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
title_full_unstemmed Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
title_sort Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
dc.creator.none.fl_str_mv Escalante Muñoz, Teresa
Rucavado Romero, Alexandra
Fox, Jay W.
Gutiérrez, José María
author Escalante Muñoz, Teresa
author_facet Escalante Muñoz, Teresa
Rucavado Romero, Alexandra
Fox, Jay W.
Gutiérrez, José María
author_role author
author2 Rucavado Romero, Alexandra
Fox, Jay W.
Gutiérrez, José María
author2_role author
author
author
dc.subject.es_ES.fl_str_mv Snake venom
Metalloproteinases
Hemorrhage
Capillary vessels
Basement membrane
Disintegrin-like domain
Cysteine-rich domain
Collagens
Perlecan
Nidogen
topic Snake venom
Metalloproteinases
Hemorrhage
Capillary vessels
Basement membrane
Disintegrin-like domain
Cysteine-rich domain
Collagens
Perlecan
Nidogen
description Versión final del documento embargada hasta 2081-08 por política editorial
publishDate 2011
dc.date.issued.none.fl_str_mv 2011-08-24
dc.date.accessioned.none.fl_str_mv 2017-02-27T15:53:36Z
dc.date.available.none.fl_str_mv 2017-02-27T15:53:36Z
dc.type.none.fl_str_mv artículo original
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info:eu-repo/semantics/article
format article
dc.identifier.citation.none.fl_str_mv http://www.sciencedirect.com/science/article/pii/S187439191100128X
dc.identifier.issn.none.fl_str_mv 1874-3919
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10669/29556
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1016/j.jprot.2011.03.026
dc.identifier.codproyecto.none.fl_str_mv 741-A7-604
741-A7-502
741-B0-606
dc.identifier.pmid.none.fl_str_mv 21447411
url http://www.sciencedirect.com/science/article/pii/S187439191100128X
https://hdl.handle.net/10669/29556
http://dx.doi.org/10.1016/j.jprot.2011.03.026
identifier_str_mv 1874-3919
741-A7-604
741-A7-502
741-B0-606
21447411
dc.language.iso.es_ES.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv acceso embargado
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info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv acceso embargado
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eu_rights_str_mv embargoedAccess
dc.source.es_ES.fl_str_mv Journal of Proteomics; Volumen 74, Número 9, 2011
dc.source.none.fl_str_mv reponame:Kérwá
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Kérwá
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spelling Escalante Muñoz, Teresa86d9e00a-76f8-4552-9d02-a03587d50166600Rucavado Romero, Alexandraf62bf3bf-c612-451f-90ef-a366ebb3f4b5600Fox, Jay W.9b8320ba-4241-4f7e-9982-b24409e85c45600Gutiérrez, José María6a9bac5f-130f-4977-8ddf-ab97fcafacc46002017-02-27T15:53:36Z2017-02-27T15:53:36Z2011-08-24http://www.sciencedirect.com/science/article/pii/S187439191100128X1874-3919https://hdl.handle.net/10669/29556http://dx.doi.org/10.1016/j.jprot.2011.03.026741-A7-604741-A7-502741-B0-60621447411Versión final del documento embargada hasta 2081-08 por política editorialHemorrhage is one of the most significant effects in envenomings induced by viperid snakebites. Damage to the microvasculature, induced by snake venom metalloproteinases (SVMPs), is the main event responsible for this effect. The precise mechanism by which SVMPs disrupt the microvasculature has remained elusive, although recent developments provide valuable clues to deciphering the details of this pathological effect. The main targets of hemorrhagic SVMPs are components of basement membrane (BM) and surrounding extracellular matrix (ECM), which provide mechanical stability to capillaries. P-III SVMPs, comprising disintegrin-like and cysteine-rich domains in addition to the catalytic domain, are more potent hemorrhagic toxins than P-I SVMPs, constituted only by the metalloproteinase domain. This is likely due to the presence of exosites in the additional domains, which contribute to the binding of SVMPs to relevant targets in the microvasculature. Recent in vivo studies have shown that P-III SVMPs are preferentially located in microvessels. On the other hand, the structural determinants responsible for the different hemorrhagic potential of P-I SVMPs remain largely unknown, although backbone flexibility in a loop located near the active site is likely to play a role. Moreover, hemorrhagic and non-hemorrhagic SVMPs differ in their capacity to hydrolyze in vivo key BM proteins, such as type IV collagen and perlecan, as well as other ECM proteins, like types VI and XV collagens, which play a critical role by connecting BM components to perivascular fibrillar collagens. The evidence gathered support a two-step model for the pathogenesis of SVMP-induced hemorrhage: initially, hemorrhagic SVMPs bind to and hydrolyze components of the BM and associated extracellular matrix proteins that play a key role in the mechanical stability of BM. In conditions of normal blood flow in the tissues, such cleavage results in the weakening, distension and eventual disruption of capillary wall due to the action of biophysical forces operating in vivo.Universidad de Costa Rica/[741-A7-604]/UCR/Costa RicaUniversidad de Costa Rica/[741-A7-502]/UCR/Costa RicaUniversidad de Costa Rica/[741-B0-606]/UCR/Costa RicaInternational Foundation for Science//IFS/SueciaOrganisation for the Prohibition of Chemical Weapons/[F/4096-1]/OPCW/Paises BajosNetwork for Research and Training in Tropical Diseases in Central America/[2-N-2008]/NeTropica/Network for Research and Training in Tropical Diseases in Central America/[01-N-2010]/NeTropica/University of Virginia School of Medicine//J.W.F./Estados UnidosUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)en_USacceso embargadohttp://purl.org/coar/access_right/c_f1cfinfo:eu-repo/semantics/embargoedAccessJournal of Proteomics; Volumen 74, Número 9, 2011reponame:Kérwáinstname:Universidad de Costa Ricainstacron:UCRSnake venomMetalloproteinasesHemorrhageCapillary vesselsBasement membraneDisintegrin-like domainCysteine-rich domainCollagensPerlecanNidogenKey events in microvascular damage induced by snake venom hemorrhagic metalloproteinasesartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleTHUMBNAIL320_2011_J.Proteomics_Escalante_SVMP_hemorrhage_review.pdf.jpg320_2011_J.Proteomics_Escalante_SVMP_hemorrhage_review.pdf.jpgGenerated Thumbnailimage/jpeg3556https://www.kerwa.ucr.ac.cr/bitstreams/56eb8c2b-0ba2-4381-92a3-7ddfd126ab3b/downloada63dfdd6bfe9f2199e0527add45d1bf6MD54ORIGINAL320_2011_J.Proteomics_Escalante_SVMP_hemorrhage_review.pdf320_2011_J.Proteomics_Escalante_SVMP_hemorrhage_review.pdfVersión finalapplication/pdf1924633https://www.kerwa.ucr.ac.cr/bitstreams/6e79f7c7-7f24-4a0d-8a98-c022e0a87362/downloadbc7a4426b2786ee92345404280cc66edMD51LICENSElicense.txtlicense.txttext/plain; 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