Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom

The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was...

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Autores: Chacur, Marucia, Picolo, Gisele, Gutiérrez, José María, Teixeira, Catarina de Fátima, Cury, Yara
Tipo de recurso: artículo
Fecha de publicación:2001
País:Costa Rica
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/29476
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S0041010100002543
https://hdl.handle.net/10669/29476
Access Level:acceso embargado
Palabra clave:Bothrops asper venom
Hyperalgesia
Bradykinin
Leukotrienes
Snake venom
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dc.title.es_ES.fl_str_mv Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
title Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
spellingShingle Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
Chacur, Marucia
Bothrops asper venom
Hyperalgesia
Bradykinin
Leukotrienes
Snake venom
title_short Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
title_full Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
title_fullStr Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
title_full_unstemmed Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
title_sort Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
dc.creator.none.fl_str_mv Chacur, Marucia
Picolo, Gisele
Gutiérrez, José María
Teixeira, Catarina de Fátima
Cury, Yara
author Chacur, Marucia
author_facet Chacur, Marucia
Picolo, Gisele
Gutiérrez, José María
Teixeira, Catarina de Fátima
Cury, Yara
author_role author
author2 Picolo, Gisele
Gutiérrez, José María
Teixeira, Catarina de Fátima
Cury, Yara
author2_role author
author
author
author
dc.subject.es_ES.fl_str_mv Bothrops asper venom
Hyperalgesia
Bradykinin
Leukotrienes
Snake venom
topic Bothrops asper venom
Hyperalgesia
Bradykinin
Leukotrienes
Snake venom
description The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B2 receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A2. Inhibition of the lipoxygenase pathway by NDGA abrogated the algogenic phenomenon. The hyperalgesic response was not modified by pretreatment with indomethacin, an inhibitor of the cyclo-oxygenase pathway, by meloxicam, an inhibitor of the type 2 cyclo-oxygenase pathway, by the PAF receptor antagonist BN52021 or by anti-TNF-α or anti-interleukin 1 antibodies. Intraplantar injection of the venom also caused an oedematogenic response which was not modified by any of these pharmacological treatments. These results suggest that hyperalgesia induced by Bothrops asper venom is, at least partially, mediated by bradykinin, phospholipase A2 activity and leukotrienes. Distinct mechanisms are involved in the development of hyperalgesia and oedema induced by the venom.
publishDate 2001
dc.date.issued.none.fl_str_mv 2001-08
dc.date.accessioned.none.fl_str_mv 2017-01-31T16:42:20Z
dc.date.available.none.fl_str_mv 2017-01-31T16:42:20Z
dc.type.none.fl_str_mv artículo original
http://purl.org/coar/resource_type/c_2df8fbb1
info:eu-repo/semantics/article
format article
dc.identifier.citation.none.fl_str_mv http://www.sciencedirect.com/science/article/pii/S0041010100002543
dc.identifier.issn.none.fl_str_mv 0041-0101
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10669/29476
dc.identifier.doi.none.fl_str_mv 10.1016/S0041-0101(00)00254-3
dc.identifier.pmid.none.fl_str_mv 11306127
url http://www.sciencedirect.com/science/article/pii/S0041010100002543
https://hdl.handle.net/10669/29476
identifier_str_mv 0041-0101
10.1016/S0041-0101(00)00254-3
11306127
dc.language.iso.es_ES.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv acceso embargado
http://purl.org/coar/access_right/c_f1cf
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv acceso embargado
http://purl.org/coar/access_right/c_f1cf
eu_rights_str_mv embargoedAccess
dc.source.es_ES.fl_str_mv Toxicon; Volumen 39, Número 8, 2001
dc.source.none.fl_str_mv reponame:Kérwá
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Kérwá
collection Kérwá
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spelling Chacur, Maruciaab0e38b5-23a1-4ee8-8de4-9ab2c1ab3291-1Picolo, Gisele3aa9be37-1450-4770-bbb3-a5cbdefdd369600Gutiérrez, José María6a9bac5f-130f-4977-8ddf-ab97fcafacc4600Teixeira, Catarina de Fátimadfc1592b-68ea-44e6-ae67-e9fcf1d6bb30600Cury, Yara055a9546-fb04-4c13-b42b-05b2e3d5bb626002017-01-31T16:42:20Z2017-01-31T16:42:20Z2001-08http://www.sciencedirect.com/science/article/pii/S00410101000025430041-0101https://hdl.handle.net/10669/2947610.1016/S0041-0101(00)00254-311306127The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B2 receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A2. Inhibition of the lipoxygenase pathway by NDGA abrogated the algogenic phenomenon. The hyperalgesic response was not modified by pretreatment with indomethacin, an inhibitor of the cyclo-oxygenase pathway, by meloxicam, an inhibitor of the type 2 cyclo-oxygenase pathway, by the PAF receptor antagonist BN52021 or by anti-TNF-α or anti-interleukin 1 antibodies. Intraplantar injection of the venom also caused an oedematogenic response which was not modified by any of these pharmacological treatments. These results suggest that hyperalgesia induced by Bothrops asper venom is, at least partially, mediated by bradykinin, phospholipase A2 activity and leukotrienes. Distinct mechanisms are involved in the development of hyperalgesia and oedema induced by the venom.Fundação de Amparo à Pesquisa do Estado de São Paulo/[98/00257-0]/FAPESP/BrasilInstituto Butantan///BrasilUniversidad de Costa Rica//UCR/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)en_USacceso embargadohttp://purl.org/coar/access_right/c_f1cfinfo:eu-repo/semantics/embargoedAccessToxicon; Volumen 39, Número 8, 2001reponame:Kérwáinstname:Universidad de Costa Ricainstacron:UCRBothrops asper venomHyperalgesiaBradykininLeukotrienesSnake venomPharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venomartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleTHUMBNAIL178_2001_Toxicon_Chacur_hyperalgesia_B.asper_pharmacology.pdf.jpg178_2001_Toxicon_Chacur_hyperalgesia_B.asper_pharmacology.pdf.jpgGenerated Thumbnailimage/jpeg4939https://www.kerwa.ucr.ac.cr/bitstreams/5fd3ccae-a91e-4d8c-9b0a-2974f2514a06/download89b9d264a740006c1bd7545fa0dc08d0MD54ORIGINAL178_2001_Toxicon_Chacur_hyperalgesia_B.asper_pharmacology.pdf178_2001_Toxicon_Chacur_hyperalgesia_B.asper_pharmacology.pdfapplication/pdf317093https://www.kerwa.ucr.ac.cr/bitstreams/4af7c6ed-6efb-4ab1-8843-11431a5258e6/downloadf6f086212ac156259bed6dcc25ece31cMD51LICENSElicense.txtlicense.txttext/plain; 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