Introduction of the American/Asian genotype of Dengue-2 virus into Yucatán state, México
ABSTRACT: A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asia...
| Authors: | , , , , , , , , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2004 |
| Country: | Colombia |
| Institution: | Universidad de Antioquia |
| Repository: | Repositorio UdeA |
| Language: | English |
| OAI Identifier: | oai:bibliotecadigital.udea.edu.co:10495/32043 |
| Online Access: | https://hdl.handle.net/10495/32043 |
| Access Level: | Open access |
| Keyword: | Distribución por Edad Age Distribution Anticuerpos Antivirales Antibodies, Viral Dengue Virus del Dengue Dengue Virus Brotes de Enfermedades Disease Outbreaks Genotipo Genotype Dengue Grave Severe Dengue |
| Summary: | ABSTRACT: A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic. |
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