Colombian experience in the treatment of hepatitis c with direct-acting antiviral agents
There are few published real-world studies on hepatitis C in Latin America. This paper describes a cohort of Colombian subjects treated with direct-acting antiviral agents. A total of 195 patients from 5 hepatology centers in 4 Colombian cities were retrospectively studied. For each patient, serum b...
| Autores: | , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | Colombia |
| Recursos: | Universidad del Rosario |
| Repositorio: | Repositorio EdocUR - U. Rosario |
| Idioma: | español |
| OAI Identifier: | oai:repository.urosario.edu.co:10336/22572 |
| Acesso em linha: | https://repository.urosario.edu.co/handle/10336/22572 |
| Access Level: | acceso abierto |
| Palavra-chave: | Alanine aminotransferase Antivirus agent Aspartate aminotransferase Asunaprevir Biological marker Daclatasvir Daclatasvir plus ribavirin Daclatasvir plus simeprevir Dasabuvir Ledipasvir Ledipasvir plus ribavirin Ledipasvir plus sofosbuvir Ombitasvir Paritaprevir Paritaprevir plus ribavirin Ribavirin Ribavirin plus sofosbuvir Ritonavir Simeprevir Sofosbuvir Unclassified drug Virus rna Adult Aged Alanine aminotransferase blood level Anemia Anxiety disorder Article Aspartate aminotransferase blood level Asthenia Brain disease Cholelithiasis Cohort analysis Colombia Diarrhea Drug efficacy Fatigue Female Genotype Headache Hepatitis c Human Intermethod comparison Liver cirrhosis Liver toxicity Liver transplantation Major clinical study Male Multicenter study Nausea Nonhuman Pruritus Rash Retrospective study Sustained virologic response Treatment outcome Virus load Vomiting Clinical trial Combination drug therapy Genetics Hepacivirus Middle aged Nonparametric test Antiviral agents Humans Retrospective studies Viral load Chronic hepatitis Drug therapy viral combination nonparametric Rna Statistics |
| Resumo: | There are few published real-world studies on hepatitis C in Latin America. This paper describes a cohort of Colombian subjects treated with direct-acting antiviral agents. A total of 195 patients from 5 hepatology centers in 4 Colombian cities were retrospectively studied. For each patient, serum biomarkers were obtained, and Child-Pugh, MELD, cirrhosis and fibrosis stage were calculated. Additionally, viral load was quantified at initiation, end of treatment and at 12 weeks of completion. Adverse effects were recorded. Patients with liver transplant were compared with non-transplanted patients in terms of serum biomarkers. The patients had received 9 different regimes. The most prevalent viral genotype was 1b (81.5%). Overall, 186 patients (95.4%) attained sustained virologic response. When comparing transplanted vs. non-transplanted patients, those in the non-transplanted group were more likely to have cirrhosis (52.6% vs. 12.5%, p = 0.0004). Pre-treatment viral load was higher in the transplant group (1 743 575 IQR = 1 038 062-4 252 719 vs. 345 769 IQR = 125 806-842 239; p less than 0.0001) as well as ALT and AST levels (82.5 IQR 43.5-115.5 vs. 37.0 IQR = 24.7-73.3; p = 0.0009 and 70 IQR = 41-140 vs. 37 IQR = 24-68; p = 0.004 respectively). Adverse events were reported by 28.7% of the patients; asthenia (5.6%) was the most prevalent. Our results are comparable with those from other countries in terms of therapy and biomarkers. However, our cohort reported less adverse events. Further research is needed in the region. © 2019, Instituto de Investigaciones Medicas. All rights reserved. |
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