Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance

14 p.

Detalles Bibliográficos
Autores: Bautista Amorocho, Henry, Castellanos Domínguez, Yeny Zulay, Rodríguez Villamizar, Laura Andrea, Velandia Cruz, Sindi Alejandra, Becerra Peña, Jeysson Andrey, Farfán García, Ana Elvira
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Colombia
Institución:Universidad de Santander
Repositorio:Repositorio Universidad de Santander
Idioma:inglés
OAI Identifier:oai:repositorio.udes.edu.co:001/3264
Acceso en línea:https://repositorio.udes.edu.co/handle/001/3264
Access Level:acceso abierto
Palabra clave:Epidemiology
Risk Factors
Genotypes of HBV
HIV-Infected Patients
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spelling Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominanceBautista Amorocho, HenryCastellanos Domínguez, Yeny ZulayRodríguez Villamizar, Laura AndreaVelandia Cruz, Sindi AlejandraBecerra Peña, Jeysson AndreyFarfán García, Ana ElviraEpidemiologyRisk FactorsGenotypes of HBVHIV-Infected Patients14 p.Abstract Introduction: Chronic hepatitis B virus (HBV) infection is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals. HIV-positive patients are commonly co-infected with HBV due to shared routes of transmission. Objectives: Our aim was to determine the risk factors, prevalence, genotypes, and mutations of the Surface S gene of HBV, and occult hepatitis B infection (OBI) among patients infected with HIV in a northeastern Colombian city. Methods: A cross-sectional study was conducted with 275 HIV-positive patients attending an outpatient clinic in Bucaramanga, Colombia during 2009–2010. Blood samples were collected and screened for serological markers of HBV (anti-HBs, anti-HBc and HBsAg) through ELISA assay. Regardless of their serological profile, all samples were tested for the HBV S gene by nested-PCR and HBV genotypes were determined by phylogenetic inference. Clinical records were used to examine demographic, clinical, virological, immunological and antiretroviral therapy (ART) variables of HIV infection. Results: Participants were on average 37¡11 years old and 65.1% male. The prevalence of HIV-HBV coinfection was 12% (95%CI 8.4–16.4) of which 3.3% had active HBV infection and 8.7% OBI. The prevalence of HIV-HBV coinfection was associated with AIDS stage and ART treatment. Sequence analysis identifiedgenotype F, subgenotype F3 in 93.8% of patients and genotype A in 6.2% of patients. A C149R mutation, which may have resulted from failure in HBsAg detection, was found in one patient with OBI. Conclusions: The present study found a high prevalence of HIV-HBV coinfection with an incidence of OBI 2.6-fold higher compared to active HBV infection. These findings suggest including HBV DNA testing to detect OBI in addition to screening for HBV serological markers in HIV patients.2019-07-05T14:44:15Z2019-07-05T14:44:15Z2014-12-02Artículo de revistahttp://purl.org/coar/resource_type/c_6501Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdf10.1371/journal.pone.01142721932-6203https://repositorio.udes.edu.co/handle/001/3264https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114272&type=printablereponame:Repositorio Universidad de Santanderinstname:Universidad de Santanderinstacron:Universidad de SantanderengPlos OneDerechos Reservados - Universidad de Santander, 2014info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/2023-10-10T17:21:05Z
dc.title.none.fl_str_mv Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
title Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
spellingShingle Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
Bautista Amorocho, Henry
Epidemiology
Risk Factors
Genotypes of HBV
HIV-Infected Patients
title_short Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
title_full Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
title_fullStr Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
title_full_unstemmed Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
title_sort Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
dc.creator.none.fl_str_mv Bautista Amorocho, Henry
Castellanos Domínguez, Yeny Zulay
Rodríguez Villamizar, Laura Andrea
Velandia Cruz, Sindi Alejandra
Becerra Peña, Jeysson Andrey
Farfán García, Ana Elvira
author Bautista Amorocho, Henry
author_facet Bautista Amorocho, Henry
Castellanos Domínguez, Yeny Zulay
Rodríguez Villamizar, Laura Andrea
Velandia Cruz, Sindi Alejandra
Becerra Peña, Jeysson Andrey
Farfán García, Ana Elvira
author_role author
author2 Castellanos Domínguez, Yeny Zulay
Rodríguez Villamizar, Laura Andrea
Velandia Cruz, Sindi Alejandra
Becerra Peña, Jeysson Andrey
Farfán García, Ana Elvira
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiology
Risk Factors
Genotypes of HBV
HIV-Infected Patients
topic Epidemiology
Risk Factors
Genotypes of HBV
HIV-Infected Patients
description 14 p.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-02
2019-07-05T14:44:15Z
2019-07-05T14:44:15Z
dc.type.none.fl_str_mv Artículo de revista
http://purl.org/coar/resource_type/c_6501
Text
info:eu-repo/semantics/article
http://purl.org/redcol/resource_type/ART
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 10.1371/journal.pone.0114272
1932-6203
https://repositorio.udes.edu.co/handle/001/3264
identifier_str_mv 10.1371/journal.pone.0114272
1932-6203
url https://repositorio.udes.edu.co/handle/001/3264
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Plos One
dc.rights.none.fl_str_mv Derechos Reservados - Universidad de Santander, 2014
info:eu-repo/semantics/openAccess
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
rights_invalid_str_mv Derechos Reservados - Universidad de Santander, 2014
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114272&type=printable
reponame:Repositorio Universidad de Santander
instname:Universidad de Santander
instacron:Universidad de Santander
instname_str Universidad de Santander
instacron_str Universidad de Santander
institution Universidad de Santander
reponame_str Repositorio Universidad de Santander
collection Repositorio Universidad de Santander
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