Use of erlotinib throughout pregnancy: a case-report of a patient with metastatic lung adenocarcinoma
The use of erlotinib throughout pregnancy has not been previously reported. We present the case of a 40 year-old female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | Colombia |
| Institución: | Universidad El Bosque |
| Repositorio: | Repositorio U. El Bosque |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unbosque.edu.co:20.500.12495/4083 |
| Acceso en línea: | http://hdl.handle.net/20.500.12495/4083 https://doi.org/10.1016/j.lungcan.2012.03.026 https://repositorio.unbosque.edu.co |
| Access Level: | acceso abierto |
| Palabra clave: | Neoplasias pulmonares Neoplasias del sistema respiratorio Embarazo Lung cancer Treatment Metastasis Non-small cell lung carcinoma Lung adenocarcinoma Erlotinib Pregnancy EGFR tyrosine kinase inhibitor |
| Sumario: | The use of erlotinib throughout pregnancy has not been previously reported. We present the case of a 40 year-old female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150 mg once daily. After two and a half months of treatment a fourteen-week pregnancy was documented, and after informing on fetal risks secondary to erlotinib use and maternal risks secondary to treatment withholding, she decided to continue with treatment under clinical surveillance by both the oncology and obstetrics clinics. At thirty-three weeks gestation a live born 1600 g female was born by caesarean section without evidence of congenital malformations. Imaging assessment after eight months of treatment showed complete bone and central nervous system response and partial lung and mediastinal response. The patient is currently undergoing the 11th month of treatment and is asymptomatic, the baby is 4 months old and is in good health. |
|---|