Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma

Introduction: Papillary thyroid carcinoma is the most common endocrine neoplasm; therefore, markers with possible prognostic utility have been evaluated.Objective: To analyze the presence of RET/PTC1 rearrangement, lymphocytic thyroiditis and associated clinical features in patients with papillary t...

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Autores: Rubio Gómez, Cladelis, Rojas, William, Polo, José Fernando, Alvarado, Alejandra, Chaparro, Diana, Torres Tobar, Lilian, Gutiérrez Castañeda, Luz Dary
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Colombia
Institución:Fundación Universitaria de Ciencias de la Salud - FUCS
Repositorio:Repositorio Digital Institucional ReDi
Idioma:inglés
español
OAI Identifier:oai:repositorio.fucsalud.edu.co:001/1951
Acceso en línea:https://repositorio.fucsalud.edu.co/handle/001/1951
Access Level:acceso abierto
Palabra clave:Papillary Thyroid Carcinoma
Thyroiditis;
Gene Rearrangement
Carcinoma papilar
Tiroiditis
Reordenamiento génico
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oai_identifier_str oai:repositorio.fucsalud.edu.co:001/1951
network_acronym_str CO
network_name_str Colombia
repository_id_str
dc.title.none.fl_str_mv Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
Ausencia del rearreglo RET/PTC1 en una muestra de sujetos colombianos con carcinoma papilar de tiroides
title Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
spellingShingle Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
Rubio Gómez, Cladelis
Papillary Thyroid Carcinoma
Thyroiditis;
Gene Rearrangement
Carcinoma papilar
Tiroiditis
Reordenamiento génico
title_short Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
title_full Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
title_fullStr Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
title_full_unstemmed Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
title_sort Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinoma
dc.creator.none.fl_str_mv Rubio Gómez, Cladelis
Rojas, William
Polo, José Fernando
Alvarado, Alejandra
Chaparro, Diana
Torres Tobar, Lilian
Gutiérrez Castañeda, Luz Dary
author Rubio Gómez, Cladelis
author_facet Rubio Gómez, Cladelis
Rojas, William
Polo, José Fernando
Alvarado, Alejandra
Chaparro, Diana
Torres Tobar, Lilian
Gutiérrez Castañeda, Luz Dary
author_role author
author2 Rojas, William
Polo, José Fernando
Alvarado, Alejandra
Chaparro, Diana
Torres Tobar, Lilian
Gutiérrez Castañeda, Luz Dary
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Papillary Thyroid Carcinoma
Thyroiditis;
Gene Rearrangement
Carcinoma papilar
Tiroiditis
Reordenamiento génico
topic Papillary Thyroid Carcinoma
Thyroiditis;
Gene Rearrangement
Carcinoma papilar
Tiroiditis
Reordenamiento génico
description Introduction: Papillary thyroid carcinoma is the most common endocrine neoplasm; therefore, markers with possible prognostic utility have been evaluated.Objective: To analyze the presence of RET/PTC1 rearrangement, lymphocytic thyroiditis and associated clinical features in patients with papillary thyroid cancer treated at the Hospital de San José in Bogotá, Colombia.Materials and methods: Clinical records of patients with complete thyroidectomy and diagnosis of papillary cancer were retrospectively identified. RNA was extracted from tumor tissue, and cDNA was obtained using inverse transcriptase to detect the rearrangement of the RET/PTC1 gene by means of qPCR.Results: 55 patients with papillary thyroid cancer were selected; 93% were females, and the mean age was 45.8 years. The most frequent histological variant was classic (49%). A relationship was found between lymphocytic thyroiditis and the number of positive nodes in segments other than central draining, as well as thyroiditis and antithyroid antibody value. No RET/PTC1 rearrangement expression was found.Conclusions: A relationship between lymphocytic thyroiditis and the number of positive nodes in segments other than central draining was found. Other molecular markers should be searched to differentiate the prognosis of these patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-01
2022-01-31T21:17:52Z
2022-01-31T21:17:52Z
dc.type.none.fl_str_mv Artículo de revista
http://purl.org/coar/resource_type/c_6501
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Text
https://purl.org/redcol/resource_type/WP
http://purl.org/coar/version/c_970fb48d4fbd8a85
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.fucsalud.edu.co/handle/001/1951
url https://repositorio.fucsalud.edu.co/handle/001/1951
dc.language.none.fl_str_mv eng
spa
language eng
spa
dc.relation.none.fl_str_mv Revista de la Facultad de Medicina Universidad Nacional de Colombia ISSN:0120-0011 Vol.67 Núm.4 (2019)
628
4
623
67
Revista de la Facultad de Medicina Universidad Nacional de Colombia
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional de Colombia
Colombia
publisher.none.fl_str_mv Universidad Nacional de Colombia
Colombia
dc.source.none.fl_str_mv https://revistas.unal.edu.co/index.php/revfacmed/article/view/64560
reponame:Repositorio Digital Institucional ReDi
instname:Fundación Universitaria de Ciencias de la Salud - FUCS
instacron:Fundación Universitaria de Ciencias de la Salud - FUCS
instname_str Fundación Universitaria de Ciencias de la Salud - FUCS
instacron_str Fundación Universitaria de Ciencias de la Salud - FUCS
institution Fundación Universitaria de Ciencias de la Salud - FUCS
reponame_str Repositorio Digital Institucional ReDi
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spelling Absence of RET/PTC1 rearrangement in a sample of Colombian individuals with papillary thyroid carcinomaAusencia del rearreglo RET/PTC1 en una muestra de sujetos colombianos con carcinoma papilar de tiroidesRubio Gómez, CladelisRojas, WilliamPolo, José FernandoAlvarado, AlejandraChaparro, DianaTorres Tobar, LilianGutiérrez Castañeda, Luz DaryPapillary Thyroid CarcinomaThyroiditis;Gene RearrangementCarcinoma papilarTiroiditisReordenamiento génicoIntroduction: Papillary thyroid carcinoma is the most common endocrine neoplasm; therefore, markers with possible prognostic utility have been evaluated.Objective: To analyze the presence of RET/PTC1 rearrangement, lymphocytic thyroiditis and associated clinical features in patients with papillary thyroid cancer treated at the Hospital de San José in Bogotá, Colombia.Materials and methods: Clinical records of patients with complete thyroidectomy and diagnosis of papillary cancer were retrospectively identified. RNA was extracted from tumor tissue, and cDNA was obtained using inverse transcriptase to detect the rearrangement of the RET/PTC1 gene by means of qPCR.Results: 55 patients with papillary thyroid cancer were selected; 93% were females, and the mean age was 45.8 years. The most frequent histological variant was classic (49%). A relationship was found between lymphocytic thyroiditis and the number of positive nodes in segments other than central draining, as well as thyroiditis and antithyroid antibody value. No RET/PTC1 rearrangement expression was found.Conclusions: A relationship between lymphocytic thyroiditis and the number of positive nodes in segments other than central draining was found. Other molecular markers should be searched to differentiate the prognosis of these patients.Introducción. El carcinoma papilar de tiroides es la neoplasia endocrina más común, por lo que se han evaluado marcadores con posible utilidad pronóstica.Objetivo. Analizar la presencia del rearreglo del RET/PTC1, tiroiditis linfocítica y características clínicas asociadas en pacientes con cáncer papilar de tiroides en el Hospital de San José de Bogotá D.C., Colombia.Materiales y métodos. Los casos con diagnóstico de cáncer papilar y tiroidectomía completa fueron seleccionados utilizando el registro de historias clínicas; el ARN se extrajo a partir del tejido tumoral y el ADNc se obtuvo utilizando una transcriptasa inversa para luego detectar el rearreglo del gen RET/PTC1 por medio de qPCR. Resultados. Se seleccionaron 55 pacientes con cáncer papilar de tiroides; 93% correspondió a género femenino, la edad promedio fue de 45.8 años y la variante histológica más frecuente fue la clásica (49%). Se evidenció una relación entre tiroiditis linfocítica y la cantidad de ganglios positivos en segmentos distintos al vaciamiento central, así como la tiroiditis y el valor de los anticuerpos antitiroideos. No se identificó la expresión del rearreglo RET/PTC1 en las muestras analizadas.Conclusiones. Se muestra una relación entre tiroiditis linfocítica y la cantidad de ganglios positivos en segmentos distintos al vaciamiento central. Se debe continuar la búsqueda de otros marcadores moleculares que permitan diferenciar el pronóstico en estos pacientes.Universidad Nacional de ColombiaColombia2022-01-31T21:17:52Z2019-10-012022-01-31T21:17:52ZArtículo de revistahttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttps://purl.org/redcol/resource_type/WPhttp://purl.org/coar/version/c_970fb48d4fbd8a856 p.application/pdfapplication/pdfhttps://repositorio.fucsalud.edu.co/handle/001/1951https://revistas.unal.edu.co/index.php/revfacmed/article/view/64560reponame:Repositorio Digital Institucional ReDiinstname:Fundación Universitaria de Ciencias de la Salud - FUCSinstacron:Fundación Universitaria de Ciencias de la Salud - FUCSengspaRevista de la Facultad de Medicina Universidad Nacional de Colombia ISSN:0120-0011 Vol.67 Núm.4 (2019)628462367Revista de la Facultad de Medicina Universidad Nacional de Colombiainfo:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf22024-02-02T18:11:07Z
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