Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-...

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Bibliographic Details
Authors: Mamtani M., Mummidi S., Ramsuran V., Pham M.-H., Maldonado R., Begum K., Valera M.S., Sanchez R., Castiblanco J., Kulkarni H., Ndung'u T., He W., Anaya, Juan-Manuel, Ahuja S.K.
Format: article
Status:Published version
Publication Date:2011
Country:Colombia
Institution:Universidad del Rosario
Repository:Repositorio EdocUR - U. Rosario
Language:English
OAI Identifier:oai:repository.urosario.edu.co:10336/22374
Online Access:https://doi.org/10.1093/infdis/jir145
https://repository.urosario.edu.co/handle/10336/22374
Access Level:Open access
Keyword:CCL3L1 chemokine
Chemokine
Chemokine receptor CCR5
Macrophage inflammatory protein 1alpha
Membrane protein
Unclassified drug
Virus receptor
Acquired immune deficiency syndrome
Adult
Article
CCR5 gene
Colombia
Controlled study
DNA polymorphism
Female
Gene
Gene dosage
Genetic susceptibility
Genetic variability
Haplotype
Human
Human cell
Human immunodeficiency virus 1
Human immunodeficiency virus infection
Major clinical study
Male
Priority journal
Protein expression
Tuberculosis
Case-Control Studies
Gene Dosage
Haplotypes
Humans
Linkage Disequilibrium
Logistic Models
Middle Aged
CCR5
Genetic
CC
Chemokines
Polymorphism
Receptors
Description
Summary:We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

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