Caracterización del gen de la dopamina B-hidroxilasa en población mestiza colombiana
Dopamine β- hidroxylase catalyzes the conversion of dopamine to norepinephrine and it is a promising target for pharmacological inventions. DβH gene polymorphisms are responsible for individual differences in dopaminergic and adrenergic tone of the central and autonomic nervous systems. Since defect...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión actualizada desde la publicación |
| Fecha de publicación: | 2013 |
| País: | Colombia |
| Institución: | Universidad del Quindío |
| Repositorio: | Repositorio Universidad del Quindío |
| Idioma: | español |
| OAI Identifier: | oai:bdigital.uniquindio.edu.co:001/4646 |
| Acceso en línea: | https://bdigital.uniquindio.edu.co/handle/001/4646 |
| Access Level: | acceso abierto |
| Palabra clave: | Población Mestiza |
| Sumario: | Dopamine β- hidroxylase catalyzes the conversion of dopamine to norepinephrine and it is a promising target for pharmacological inventions. DβH gene polymorphisms are responsible for individual differences in dopaminergic and adrenergic tone of the central and autonomic nervous systems. Since defective enzyme mutations and their frequencies vary among ethnic groups, it is justify the studies leading to the genotypic and phenotypic characterization of the enzyme in Colombian mestizos. We determined the frequencies of the alleles -2073C>T, -970C>T, 444A>G and 1603C>T DβH gene in 143 healthy adults, mestizo features, both sexes and nonconsanguineous. PCR-real time and minisequencing (SnaPshot) tecnhiques were used for the genotyping |
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