Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome

The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2...

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Detalles Bibliográficos
Autores: Lynch, Rebecca M., Mantus, Grace, Encinales, Liliana, Pacheco, Nelly, Li, Guangzhao, Porras-Ramírez, Alexandra, Rico Mendoza, Alejandro, Peng, Jin, Rengifo Pardo, Monica, Montoya Cruz, Magelda, Harris, Eva, Bethony, Jeffrey Michael, Simon, Gary L., Chang, Aileen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Colombia
Institución:Universidad El Bosque
Repositorio:Repositorio U. El Bosque
Idioma:inglés
OAI Identifier:oai:repositorio.unbosque.edu.co:20.500.12495/2069
Acceso en línea:http://hdl.handle.net/20.500.12495/2069
https://doi.org/10.1093/infdis/jiy466
Access Level:acceso abierto
Palabra clave:Anticuerpos neutralizantes
Virus zika
Virus del dengue
Guillain-Barré syndrome
Neutralizing antibody
Flavivirus
Descripción
Sumario:The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.

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