Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia

Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospita...

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Autores: VILLEGAS, ROSSANA, FRANCO, CATALINA, RENDÓN, JAVIER, TORRES, JOSÉ, JARAMILLO, PATRICIA
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Colombia
Institución:Universidad de Córdoba
Repositorio:Repositorio Institucional Unicórdoba
Idioma:español
OAI Identifier:oai:repositorio.unicordoba.edu.co:ucordoba/618
Acceso en línea:https://repositorio.unicordoba.edu.co/handle/ucordoba/618
Access Level:acceso abierto
Palabra clave:Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry
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spelling Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemiaFrecuencia de linfocitosis monoclonal de células B en familiares de pacientes con leucemia linfoide crónicaVILLEGAS, ROSSANAFRANCO, CATALINARENDÓN, JAVIERTORRES, JOSÉJARAMILLO, PATRICIAMonoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometryIntroduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.2018-03-05T20:43:56Z2018-03-05T20:43:56Z2016-05-04Artículo de revistainfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/publishedVersionTexthttps://purl.org/redcol/resource_type/ARTapplication/pdfVillegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6.1657-9534https://repositorio.unicordoba.edu.co/handle/ucordoba/618spaCopyright Universidad de Córdoba, 2016https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)reponame:Repositorio Institucional Unicórdobainstname:Universidad de Córdobainstacron:Universidad de Córdoba2020-11-24T20:15:21Z
dc.title.none.fl_str_mv Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
Frecuencia de linfocitosis monoclonal de células B en familiares de pacientes con leucemia linfoide crónica
title Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
spellingShingle Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
VILLEGAS, ROSSANA
Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry
title_short Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
title_full Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
title_fullStr Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
title_full_unstemmed Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
title_sort Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
dc.creator.none.fl_str_mv VILLEGAS, ROSSANA
FRANCO, CATALINA
RENDÓN, JAVIER
TORRES, JOSÉ
JARAMILLO, PATRICIA
author VILLEGAS, ROSSANA
author_facet VILLEGAS, ROSSANA
FRANCO, CATALINA
RENDÓN, JAVIER
TORRES, JOSÉ
JARAMILLO, PATRICIA
author_role author
author2 FRANCO, CATALINA
RENDÓN, JAVIER
TORRES, JOSÉ
JARAMILLO, PATRICIA
author2_role author
author
author
author
dc.subject.none.fl_str_mv Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry
topic Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry
description Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.
publishDate 2016
dc.date.none.fl_str_mv 2016-05-04
2018-03-05T20:43:56Z
2018-03-05T20:43:56Z
dc.type.none.fl_str_mv Artículo de revista
info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
info:eu-repo/semantics/publishedVersion
Text
https://purl.org/redcol/resource_type/ART
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Villegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6.
1657-9534
https://repositorio.unicordoba.edu.co/handle/ucordoba/618
identifier_str_mv Villegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6.
1657-9534
url https://repositorio.unicordoba.edu.co/handle/ucordoba/618
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv Copyright Universidad de Córdoba, 2016
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional (CC BY 4.0)
rights_invalid_str_mv Copyright Universidad de Córdoba, 2016
https://creativecommons.org/licenses/by/4.0/
Atribución 4.0 Internacional (CC BY 4.0)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Unicórdoba
instname:Universidad de Córdoba
instacron:Universidad de Córdoba
instname_str Universidad de Córdoba
instacron_str Universidad de Córdoba
institution Universidad de Córdoba
reponame_str Repositorio Institucional Unicórdoba
collection Repositorio Institucional Unicórdoba
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score 15,198674

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