Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets

28 páginas

Detalles Bibliográficos
Autores: Lizcano Losada, Fernando, García Serrano, Jeison
Tipo de recurso: artículo
Fecha de publicación:2012
País:Colombia
Institución:Universidad de la Sabana
Repositorio:Repositorio Universidad de la Sabana
Idioma:inglés
OAI Identifier:oai:intellectum.unisabana.edu.co:10818/27570
Acceso en línea:http://www.mdpi.com/1424-8247/5/9/963
http://hdl.handle.net/10818/27570
Access Level:acceso abierto
Palabra clave:Neoplasia
Epigenomics
Histone demethylases
Histone demethylases with a jumonji domain
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spelling Epigenetic control and cancer: the potential of histone demethylases as therapeutic targetsLizcano Losada, FernandoGarcía Serrano, JeisonNeoplasiaEpigenomicsHistone demethylasesHistone demethylases with a jumonji domain28 páginasThe development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript.Pharmaceuticals10/18/2016 14:542016-10-18T19:54:09Z2012-06-26articlepublishedVersioninfo:eu-repo/semantics/articleapplication/pdf1424-8247http://www.mdpi.com/1424-8247/5/9/963http://hdl.handle.net/10818/2757010.3390/ph5090963Universidad de La SabanaIntellectum Repositorio Universidad de La Sabanareponame:Repositorio Universidad de la Sabanainstname:Universidad de la Sabanainstacron:Universidad de la SabanaengPharmaceuticals 2012, 5, 963-990Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccess2022-05-10T10:17:12Z
dc.title.none.fl_str_mv Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
spellingShingle Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
Lizcano Losada, Fernando
Neoplasia
Epigenomics
Histone demethylases
Histone demethylases with a jumonji domain
title_short Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_full Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_fullStr Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_full_unstemmed Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_sort Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
dc.creator.none.fl_str_mv Lizcano Losada, Fernando
García Serrano, Jeison
author Lizcano Losada, Fernando
author_facet Lizcano Losada, Fernando
García Serrano, Jeison
author_role author
author2 García Serrano, Jeison
author2_role author
dc.subject.none.fl_str_mv Neoplasia
Epigenomics
Histone demethylases
Histone demethylases with a jumonji domain
topic Neoplasia
Epigenomics
Histone demethylases
Histone demethylases with a jumonji domain
description 28 páginas
publishDate 2012
dc.date.none.fl_str_mv 10/18/2016 14:54
2012-06-26
2016-10-18T19:54:09Z
dc.type.none.fl_str_mv article
publishedVersion
info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv 1424-8247
http://www.mdpi.com/1424-8247/5/9/963
http://hdl.handle.net/10818/27570
10.3390/ph5090963
identifier_str_mv 1424-8247
10.3390/ph5090963
url http://www.mdpi.com/1424-8247/5/9/963
http://hdl.handle.net/10818/27570
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceuticals 2012, 5, 963-990
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pharmaceuticals
publisher.none.fl_str_mv Pharmaceuticals
dc.source.none.fl_str_mv Universidad de La Sabana
Intellectum Repositorio Universidad de La Sabana
reponame:Repositorio Universidad de la Sabana
instname:Universidad de la Sabana
instacron:Universidad de la Sabana
instname_str Universidad de la Sabana
instacron_str Universidad de la Sabana
institution Universidad de la Sabana
reponame_str Repositorio Universidad de la Sabana
collection Repositorio Universidad de la Sabana
_version_ 1825050773598240768
score 15,81155

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