Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Colombia |
| Institución: | Universidad ICESI |
| Repositorio: | Repositorio ICESI |
| Idioma: | inglés |
| OAI Identifier: | oai:repository.icesi.edu.co:10906/79907 |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S1381514814001746 http://hdl.handle.net/10906/79907 http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006 |
| Access Level: | acceso abierto |
| Palabra clave: | Hydrogels Dicarboxylic acids Drug release Viscoelasticity Biochemistry research Métodos de investigación en bioquímica |
| Sumario: | Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs and temperatures, and it was discovered that these properties depend particularly on the pH of the environment. Creep-recovery and stress-relaxation studies were performed to determine mechanical properties and the chitosan/succinic acid hydrogels exhibited a completely viscous behavior. Thermal studies were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC results revealed that the materials obtained are completely amorphous. Acetaminophen was used as a positive control for the release kinetics studies. Upon fitting the results to a specific mathematical model, it was determined that the release process is controlled by diffusion and relaxation of the polymer network. |
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