Is narcolepsy a classical autoimmune disease?
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the dis...
| Authors: | , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2015 |
| Country: | Colombia |
| Institution: | Universidad del Rosario |
| Repository: | Repositorio EdocUR - U. Rosario |
| Language: | English |
| OAI Identifier: | oai:repository.urosario.edu.co:10336/22798 |
| Online Access: | https://doi.org/10.1016/j.phrs.2014.10.005 https://repository.urosario.edu.co/handle/10336/22798 |
| Access Level: | Open access |
| Keyword: | Alpha tocopherol As03 vaccine Autoantibody Autoantigen Cathepsin g Dna methyltransferase 1 Hla dqa1 antigen Hla dqb1 antigen Influenza vaccine Interleukin 4 Trib2 antibody Tumor necrosis factor alpha Unclassified drug Virus vaccine Autoimmune disease Autoimmunity Cd4+ t lymphocyte Dna polymorphism Environmental factor High risk patient Human Immune response Immunopathogenesis Influenza Narcolepsy Nonhuman Priority journal Review Streptococcus infection T lymphocyte Th1 cell Th2 cell Vaccination Animal Autoimmune diseases Genetics Immunology Influenza a virus (h1n1) Animals Autoantibodies Autoantigens Humans Influenza vaccines Adjuvant Asia syndrome H1n1 Infections human h1n1 subtype Influenza a virus |
| Summary: | Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the disease with the HLA DQB1?06:02, as well as the link with environmental factors and are important clues supporting this theory. Recently, the association between the occurrence of the disease and vaccination campaign after the 2009 H1N1 pandemic highlighted the importance to increase the knowledge in the Pandora box of the vaccines. This review discusses the last finding regarding the pathogenesis of the disease and its relationship with the H1N1 vaccines. © 2014 Elsevier Ltd. All rights reserved. |
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