Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum

Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immu...

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Detalhes bibliográficos
Autores: Patarroyo M.E., Aza-Conde J., Moreno-Vranich A., Pabón L., Varela Y., Patarroyo M.A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Colombia
Recursos:Universidad del Rosario
Repositorio:Repositorio EdocUR - U. Rosario
Idioma:inglés
OAI Identifier:oai:repository.urosario.edu.co:10336/23813
Acesso em linha:https://doi.org/10.21775/cimb.022.065
https://repository.urosario.edu.co/handle/10336/23813
Access Level:acceso abierto
Palavra-chave:Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Parasite antigen
Animals
Host-parasite interactions
protozoan
falciparum
Antigens
Malaria
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spelling Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparumPatarroyo M.E.Aza-Conde J.Moreno-Vranich A.Pabón L.Varela Y.Patarroyo M.A.Immune responseNonhumanPlasmodium falciparumAnimalHost parasite interactionImmunologyMalaria falciparumPlasmodium falciparumParasite antigenAnimalsHost-parasite interactionsPlasmodium falciparumprotozoanfalciparumAntigensMalariaLike Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induced. © 2017, Caister Academic Press. All rights reserved.Caister Academic Press20172020-05-26T00:05:39Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.21775/cimb.022.0651467303714673045https://repository.urosario.edu.co/handle/10336/23813reponame:Repositorio EdocUR - U. Rosarioinstname:Universidad del Rosarioinstacron:Universidad del Rosarioenghttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85010930947&doi=10.21775%2fcimb.022.065&partnerID=40&md5=25b87c7556274d999e66ca1804e6da9binfo:eu-repo/semantics/openAccess2022-05-02T07:37:21Z
dc.title.none.fl_str_mv Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
spellingShingle Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
Patarroyo M.E.
Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
title_short Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_full Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_fullStr Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_full_unstemmed Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_sort Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
dc.creator.none.fl_str_mv Patarroyo M.E.
Aza-Conde J.
Moreno-Vranich A.
Pabón L.
Varela Y.
Patarroyo M.A.
author Patarroyo M.E.
author_facet Patarroyo M.E.
Aza-Conde J.
Moreno-Vranich A.
Pabón L.
Varela Y.
Patarroyo M.A.
author_role author
author2 Aza-Conde J.
Moreno-Vranich A.
Pabón L.
Varela Y.
Patarroyo M.A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
topic Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
description Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induced. © 2017, Caister Academic Press. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-05-26T00:05:39Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.21775/cimb.022.065
14673037
14673045
https://repository.urosario.edu.co/handle/10336/23813
url https://doi.org/10.21775/cimb.022.065
https://repository.urosario.edu.co/handle/10336/23813
identifier_str_mv 14673037
14673045
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010930947&doi=10.21775%2fcimb.022.065&partnerID=40&md5=25b87c7556274d999e66ca1804e6da9b
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Caister Academic Press
publisher.none.fl_str_mv Caister Academic Press
dc.source.none.fl_str_mv reponame:Repositorio EdocUR - U. Rosario
instname:Universidad del Rosario
instacron:Universidad del Rosario
instname_str Universidad del Rosario
instacron_str Universidad del Rosario
institution Universidad del Rosario
reponame_str Repositorio EdocUR - U. Rosario
collection Repositorio EdocUR - U. Rosario
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score 15,812429

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