Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions

In this review article, we examined the role of mitochondria in the good functioning of the heart, and in the generation of various cardiac conditions, which are characterized by low energy production by the mitochondria and therefore, there is an increase in the loss of cardiomyocytes that leads to...

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Detalles Bibliográficos
Autores: Cañas Arboleda, Mariana, Franco-Sierra, Nicolás D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Colombia
Institución:Universidad EAFIT
Repositorio:Repositorio EAFIT
Idioma:español
OAI Identifier:oai:repository.eafit.edu.co:10784/13187
Acceso en línea:http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601
http://hdl.handle.net/10784/13187
Access Level:acceso abierto
Palabra clave:Mitochondria
Heart function
Heart failure
Mitochondrial dysfunctions
Mitocondria
Función cardíaca
Falla cardiaca
Disfunciones mitocondriales
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spelling Role of Mitochondrial Function in the Heart and its Impications in Cardiac DysfunctionsRol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacasCañas Arboleda, MarianaFranco-Sierra, Nicolás D.MitochondriaHeart functionHeart failureMitochondrial dysfunctionsMitocondriaFunción cardíacaFalla cardiacaDisfunciones mitocondrialesIn this review article, we examined the role of mitochondria in the good functioning of the heart, and in the generation of various cardiac conditions, which are characterized by low energy production by the mitochondria and therefore, there is an increase in the loss of cardiomyocytes that leads to malfunction of the heart. It has been determined that certain mitochondrial dysfunctions associated with cardiac disorders are related to alterations of the oxidative phosphorylation system, as well as to the reduction of certain structural components such as cardiolipin and the formation of supercomplexes. It is estimated that about 2.3% of the Colombian population may present prevalence to heart failure. The objective of the present review is to present the investigative advances related to cardiac diseases caused by mitochondrial dysfunction, as well the identification of different investigations directed at the creation of treatment alternatives for these pathologies, all in order to contribute to the construction of lines of work that take the mitochondria as a therapeutic target.En este artículo de revisión, examinamos el papel de la mitocondria en el buen funcionamiento del corazón, y en la generación de diversas afecciones cardíacas, las cuales están caracterizadas por una baja producción de energía por parte de las mitocondrias y, por ende, hay un aumento en la pérdida de cardiomiocitos que conlleva al mal funcionamiento del corazón. Se ha determinado, que ciertas disfunciones mitocondriales asociadas a trastornos cardíacos se relacionan con alteraciones del sistema de fosforilación oxidativa, así como, con la disminución de ciertos componentes estructurales como la cardiolipina y la formación de supercomplejos. Se estima que cerca del 2.3% de la población colombiana puede presentar una prevalencia a la falla cardíaca. La presente revisión tiene como objetivo dar a conocer los avances investigativos relacionados con enfermedades cardíacas ocasionadas por disfunción mitocondrial, así como, la identificación de diferentes investigaciones dirigidas en la creación de alternativas de tratamiento para dichas patologías, todo esto con el fin de contribuir a la construcción de líneas de trabajo que tomen a la mitocondria como blanco terapéutico.Universidad EAFITUniversidad EAFIT2017-11-072018-11-16T16:28:59Z2017-11-072018-11-16T16:28:59Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionarticlepublishedVersionArtículoapplication/pdfapplication/pdftext/html2256-43141794-9165http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601http://hdl.handle.net/10784/1318710.17230/ingciencia.13.26.9Ingeniería y Ciencia; Vol 13 No 26 (2017); 233-268Ingeniería y Ciencia; Vol 13 No 26 (2017); 233-268reponame:Repositorio EAFITinstname:Universidad EAFITinstacron:Universidad EAFITspahttp://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601Copyright (c) 2017 Mariana Cañas Arboleda, Nicolás D Franco-SierraAttribution 4.0 International (CC BY 4.0)http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAcceso abierto2020-03-01T22:36:02Z
dc.title.none.fl_str_mv Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
Rol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacas
title Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
spellingShingle Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
Cañas Arboleda, Mariana
Mitochondria
Heart function
Heart failure
Mitochondrial dysfunctions
Mitocondria
Función cardíaca
Falla cardiaca
Disfunciones mitocondriales
title_short Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
title_full Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
title_fullStr Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
title_full_unstemmed Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
title_sort Role of Mitochondrial Function in the Heart and its Impications in Cardiac Dysfunctions
dc.creator.none.fl_str_mv Cañas Arboleda, Mariana
Franco-Sierra, Nicolás D.
author Cañas Arboleda, Mariana
author_facet Cañas Arboleda, Mariana
Franco-Sierra, Nicolás D.
author_role author
author2 Franco-Sierra, Nicolás D.
author2_role author
dc.contributor.none.fl_str_mv Universidad EAFIT
dc.subject.none.fl_str_mv Mitochondria
Heart function
Heart failure
Mitochondrial dysfunctions
Mitocondria
Función cardíaca
Falla cardiaca
Disfunciones mitocondriales
topic Mitochondria
Heart function
Heart failure
Mitochondrial dysfunctions
Mitocondria
Función cardíaca
Falla cardiaca
Disfunciones mitocondriales
description In this review article, we examined the role of mitochondria in the good functioning of the heart, and in the generation of various cardiac conditions, which are characterized by low energy production by the mitochondria and therefore, there is an increase in the loss of cardiomyocytes that leads to malfunction of the heart. It has been determined that certain mitochondrial dysfunctions associated with cardiac disorders are related to alterations of the oxidative phosphorylation system, as well as to the reduction of certain structural components such as cardiolipin and the formation of supercomplexes. It is estimated that about 2.3% of the Colombian population may present prevalence to heart failure. The objective of the present review is to present the investigative advances related to cardiac diseases caused by mitochondrial dysfunction, as well the identification of different investigations directed at the creation of treatment alternatives for these pathologies, all in order to contribute to the construction of lines of work that take the mitochondria as a therapeutic target.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-07
2017-11-07
2018-11-16T16:28:59Z
2018-11-16T16:28:59Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
article
publishedVersion
Artículo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 2256-4314
1794-9165
http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601
http://hdl.handle.net/10784/13187
10.17230/ingciencia.13.26.9
identifier_str_mv 2256-4314
1794-9165
10.17230/ingciencia.13.26.9
url http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601
http://hdl.handle.net/10784/13187
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/4601
dc.rights.none.fl_str_mv Copyright (c) 2017 Mariana Cañas Arboleda, Nicolás D Franco-Sierra
Attribution 4.0 International (CC BY 4.0)
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Acceso abierto
rights_invalid_str_mv Copyright (c) 2017 Mariana Cañas Arboleda, Nicolás D Franco-Sierra
Attribution 4.0 International (CC BY 4.0)
http://creativecommons.org/licenses/by/4.0
Acceso abierto
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad EAFIT
publisher.none.fl_str_mv Universidad EAFIT
dc.source.none.fl_str_mv Ingeniería y Ciencia; Vol 13 No 26 (2017); 233-268
Ingeniería y Ciencia; Vol 13 No 26 (2017); 233-268
reponame:Repositorio EAFIT
instname:Universidad EAFIT
instacron:Universidad EAFIT
instname_str Universidad EAFIT
instacron_str Universidad EAFIT
institution Universidad EAFIT
reponame_str Repositorio EAFIT
collection Repositorio EAFIT
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score 15.812429

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