Bronquiolitis y fenotipos clínicos, hacia un manejo individualizado
Introduction: Bronchiolitis is one of the most common respiratory diseases in childhood and brings with high rates of hospitalization and costs to health services. Recently, the heterogeneity of the affected population has been identified with the emergence of clinical endotypes and phenotypes of br...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | Colombia |
| Institución: | Universidad Nacional de Colombia |
| Repositorio: | Repositorio UN |
| Idioma: | español |
| OAI Identifier: | oai:repositorio.unal.edu.co:unal/79230 |
| Acceso en línea: | https://repositorio.unal.edu.co/handle/unal/79230 |
| Access Level: | acceso abierto |
| Palabra clave: | 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría Bronchiolitis Heterogeneity Clinical phenotypes Endotypes Phenotype-specific treatment Bronquiolitis Heterogeneidad Fenotipos clínicos Endotipos Tratamiento específico por fenotipos. |
| Sumario: | Introduction: Bronchiolitis is one of the most common respiratory diseases in childhood and brings with high rates of hospitalization and costs to health services. Recently, the heterogeneity of the affected population has been identified with the emergence of clinical endotypes and phenotypes of bronchiolitis that include a change in the diagnosis and management of this disease. Methodology: A systematic review of the literature was performed in the PubMed, ScienceDirect and LILACS databases, and a manual bibliographic review of other sources was carried out. Articles evaluating the heterogeneity of bronchiolitis, clinical phenotypes, and their therapeutic implications were included. Results: 280 articles were found, applying inclusion and exclusion criteria, 28 were obtained for full-text review that were included in the systematic review in which the heterogeneity of bronchiolitis could be identified, the study of endotypes based on omics sciences, the illustration of specific clinical phenotypes and the therapeutic implications of an individualized management of bronchiolitis. Conclusions: Bronchiolitis is a heterogeneous disease. Endotypes of bronchiolitis were identified based on pathobiological mechanisms that distinguish specific groups of clinical presentation, forming bronchiolitis phenotypes that tend to a specific evolutionary course and an individual response to certain therapeutic management. Recognition of these clinical phenotypes in daily medical practice must be achieved and with it the advent of a scientific challenge for the performance of new clinical trials and longitudinal studies that achieve the standardization of these phenotypes, the application of a personalized therapy and a prognosis. individual from the development of long-term diseases such as asthma |
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