Correlation between arterial lactate and central venous lactate in children with sepsis

Introduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospecti...

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Autores: Fernández Sarmiento, Jaime, Araque, Paula, Yepes, María, Mulett, Hernando, Tovar, Ximena, Rodriguez, Fabio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Colombia
Institución:Universidad del Rosario
Repositorio:Repositorio EdocUR - U. Rosario
Idioma:inglés
OAI Identifier:oai:repository.urosario.edu.co:10336/19004
Acceso en línea:http://repository.urosario.edu.co/handle/10336/19004
Access Level:acceso abierto
Palabra clave:Enfermedades
Septicemia
Sepsis
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spelling Correlation between arterial lactate and central venous lactate in children with sepsisFernández Sarmiento, JaimeAraque, PaulaYepes, MaríaMulett, HernandoTovar, XimenaRodriguez, FabioEnfermedadesSepticemiaSepsisIntroduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospective observational study. Forty-two patients were included between the age of 1 month and 17 years, with a diagnosis of sepsis and septic shock, who were admitted to the intensive care unit of a university referral hospital. The lactate value obtained from an arterial blood sample and a central venous blood sample drawn simultaneously, and within 24 hours of admission to the unit, was recorded. Results. The median age was 2.3 years (RIC 0,3-15), with a predominance of males (71.4%), having a 2.5: 1 ratio to females. Most of the patients had septic shock (78.5%) of pulmonary origin (50.0%), followed by those of gastrointestinal origin (26.1%). Using Spearman's Rho, a 0.872 (p<0.001) correlation was found between arterial and venous lactate, which did not vary when adjusted for age (p<0.05) and the use of vasoactive drugs (p<0.05). Conclusion. There is a good correlation between arterial and venous lactate in pediatric patients with sepsis and septic shock, which is not affected by demographic variables or type of vasoactive support. Copyright © 2016 Jaime Fernández Sarmiento et al.20162019-02-04T17:40:31Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfISSN 2090-1305http://repository.urosario.edu.co/handle/10336/19004Nascente, A.P.M., Assunção, M., Guedes, C.J., Comparison of lactate values obtained from different sites and their clinical significance in patients with severe sepsis (2011) Sao Paulo Medical Journal, 129 (1), pp. 11-16reponame:Repositorio EdocUR - U. Rosarioinstname:Universidad del Rosarioinstacron:Universidad del Rosarioenghttp://downloads.hindawi.com/journals/ccrp/2016/7839739.pdfinfo:eu-repo/semantics/openAccess2019-09-19T07:37:54Z
dc.title.none.fl_str_mv Correlation between arterial lactate and central venous lactate in children with sepsis
title Correlation between arterial lactate and central venous lactate in children with sepsis
spellingShingle Correlation between arterial lactate and central venous lactate in children with sepsis
Fernández Sarmiento, Jaime
Enfermedades
Septicemia
Sepsis
title_short Correlation between arterial lactate and central venous lactate in children with sepsis
title_full Correlation between arterial lactate and central venous lactate in children with sepsis
title_fullStr Correlation between arterial lactate and central venous lactate in children with sepsis
title_full_unstemmed Correlation between arterial lactate and central venous lactate in children with sepsis
title_sort Correlation between arterial lactate and central venous lactate in children with sepsis
dc.creator.none.fl_str_mv Fernández Sarmiento, Jaime
Araque, Paula
Yepes, María
Mulett, Hernando
Tovar, Ximena
Rodriguez, Fabio
author Fernández Sarmiento, Jaime
author_facet Fernández Sarmiento, Jaime
Araque, Paula
Yepes, María
Mulett, Hernando
Tovar, Ximena
Rodriguez, Fabio
author_role author
author2 Araque, Paula
Yepes, María
Mulett, Hernando
Tovar, Ximena
Rodriguez, Fabio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedades
Septicemia
Sepsis
topic Enfermedades
Septicemia
Sepsis
description Introduction. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Methods. Longitudinal retrospective observational study. Forty-two patients were included between the age of 1 month and 17 years, with a diagnosis of sepsis and septic shock, who were admitted to the intensive care unit of a university referral hospital. The lactate value obtained from an arterial blood sample and a central venous blood sample drawn simultaneously, and within 24 hours of admission to the unit, was recorded. Results. The median age was 2.3 years (RIC 0,3-15), with a predominance of males (71.4%), having a 2.5: 1 ratio to females. Most of the patients had septic shock (78.5%) of pulmonary origin (50.0%), followed by those of gastrointestinal origin (26.1%). Using Spearman's Rho, a 0.872 (p<0.001) correlation was found between arterial and venous lactate, which did not vary when adjusted for age (p<0.05) and the use of vasoactive drugs (p<0.05). Conclusion. There is a good correlation between arterial and venous lactate in pediatric patients with sepsis and septic shock, which is not affected by demographic variables or type of vasoactive support. Copyright © 2016 Jaime Fernández Sarmiento et al.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019-02-04T17:40:31Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv ISSN 2090-1305
http://repository.urosario.edu.co/handle/10336/19004
identifier_str_mv ISSN 2090-1305
url http://repository.urosario.edu.co/handle/10336/19004
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://downloads.hindawi.com/journals/ccrp/2016/7839739.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Nascente, A.P.M., Assunção, M., Guedes, C.J., Comparison of lactate values obtained from different sites and their clinical significance in patients with severe sepsis (2011) Sao Paulo Medical Journal, 129 (1), pp. 11-16
reponame:Repositorio EdocUR - U. Rosario
instname:Universidad del Rosario
instacron:Universidad del Rosario
instname_str Universidad del Rosario
instacron_str Universidad del Rosario
institution Universidad del Rosario
reponame_str Repositorio EdocUR - U. Rosario
collection Repositorio EdocUR - U. Rosario
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score 15.811543

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