The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions

GABA ( -aminobutyric acid) is a non-protein amino acid with important physiological properties, and with considerable relevance to the food and pharmaceutical industries. Particular interest has focused on its role as an inhibitory neurotransmitter in the mammalian cerebral cortex. In this paper, we...

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Autores: Rodrigo, M. M., Esteso, M. A., Barros, M. F., Verissimo, L.M.P., Romero, C.M., Suarez, A.F., Ramosb, M. L., Valente, A.J.M., Burrows, H. D., Ribeiro, A.C.F.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:Colombia
Institución:Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:Expeditio: repositorio UTadeo
OAI Identifier:oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/9083
Acceso en línea:http://dx.doi.org/10.1016/j.jct.2016.09.014
http://hdl.handle.net/20.500.12010/9083
Access Level:acceso abierto
Palabra clave:Diffusion coefficient
Density
Activity coefficient
Aminobutyric acid
Solutions
Taylor dispersion
NMR
Soluciones (Química) -- Investigaciones
Aminoácidos -- Investigaciones
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spelling The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutionsRodrigo, M. M.Esteso, M. A.Barros, M. F.Verissimo, L.M.P.Romero, C.M.Suarez, A.F.Ramosb, M. L.Valente, A.J.M.Burrows, H. D.Ribeiro, A.C.F.Diffusion coefficientDensityActivity coefficientAminobutyric acidSolutionsTaylor dispersionNMRSoluciones (Química) -- InvestigacionesAminoácidos -- InvestigacionesGABA ( -aminobutyric acid) is a non-protein amino acid with important physiological properties, and with considerable relevance to the food and pharmaceutical industries. Particular interest has focused on its role as an inhibitory neurotransmitter in the mammalian cerebral cortex. In this paper, we report density and mutual diffusion coefficients of GABA in non-buffered aqueous solutions (0.001 to 0.100) mol·dm-3 at 298.15 K. Under these conditions, 1H and 13C NMR spectroscopy and pH measurements show that it is present predominantly as a monomeric zwitterionic species. Diffusion coefficients have been computed assuming that this behaves as the binary system GABA/water. From density and intermolecular diffusion coefficients measurements, the molar volume, hydrodynamic radii Rh, diffusion coefficients at infinitesimal concentration D0, activity coefficients and the thermodynamic factors, FT, have been estimated. Within experimental error, the hydrodynamic volume calculated from this is identical to the molar volume obtained from density measurements. From the NMR spectra and literature data, it is suggested that this amino acid diffuses in aqueous solution as a curved, coil-like hydrated zwitterionic entity.Universidad de Bogotá Jorge Tadeo Lozano2020-04-29T20:53:28Z2020-04-29T20:53:28Z2017Artículoinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/article40 páginasimage/jepgimage/pngapplication/pdfhttp://dx.doi.org/10.1016/j.jct.2016.09.014http://hdl.handle.net/20.500.12010/9083http://dx.doi.org/10.1016/j.jct.2016.09.014instname:Universidad de Bogotá Jorge Tadeo Lozanoreponame:Repositorio Institucional de la Universidad de Bogotá Jorge Tadeo LozanoBogotá, Colombiainfo:eu-repo/semantics/openAccessAbierto (Texto Completo)reponame:Expeditio: repositorio UTadeoinstname:Universidad de Bogotá Jorge Tadeo Lozanoinstacron:Universidad de Bogotá Jorge Tadeo Lozano2020-04-29T20:56:18Z
dc.title.none.fl_str_mv The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
title The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
spellingShingle The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
Rodrigo, M. M.
Diffusion coefficient
Density
Activity coefficient
Aminobutyric acid
Solutions
Taylor dispersion
NMR
Soluciones (Química) -- Investigaciones
Aminoácidos -- Investigaciones
title_short The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
title_full The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
title_fullStr The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
title_full_unstemmed The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
title_sort The structure and diffusion behaviour of the neurotransmitter - aminobutyric acid (GABA) in neutral aqueous solutions
dc.creator.none.fl_str_mv Rodrigo, M. M.
Esteso, M. A.
Barros, M. F.
Verissimo, L.M.P.
Romero, C.M.
Suarez, A.F.
Ramosb, M. L.
Valente, A.J.M.
Burrows, H. D.
Ribeiro, A.C.F.
author Rodrigo, M. M.
author_facet Rodrigo, M. M.
Esteso, M. A.
Barros, M. F.
Verissimo, L.M.P.
Romero, C.M.
Suarez, A.F.
Ramosb, M. L.
Valente, A.J.M.
Burrows, H. D.
Ribeiro, A.C.F.
author_role author
author2 Esteso, M. A.
Barros, M. F.
Verissimo, L.M.P.
Romero, C.M.
Suarez, A.F.
Ramosb, M. L.
Valente, A.J.M.
Burrows, H. D.
Ribeiro, A.C.F.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diffusion coefficient
Density
Activity coefficient
Aminobutyric acid
Solutions
Taylor dispersion
NMR
Soluciones (Química) -- Investigaciones
Aminoácidos -- Investigaciones
topic Diffusion coefficient
Density
Activity coefficient
Aminobutyric acid
Solutions
Taylor dispersion
NMR
Soluciones (Química) -- Investigaciones
Aminoácidos -- Investigaciones
description GABA ( -aminobutyric acid) is a non-protein amino acid with important physiological properties, and with considerable relevance to the food and pharmaceutical industries. Particular interest has focused on its role as an inhibitory neurotransmitter in the mammalian cerebral cortex. In this paper, we report density and mutual diffusion coefficients of GABA in non-buffered aqueous solutions (0.001 to 0.100) mol·dm-3 at 298.15 K. Under these conditions, 1H and 13C NMR spectroscopy and pH measurements show that it is present predominantly as a monomeric zwitterionic species. Diffusion coefficients have been computed assuming that this behaves as the binary system GABA/water. From density and intermolecular diffusion coefficients measurements, the molar volume, hydrodynamic radii Rh, diffusion coefficients at infinitesimal concentration D0, activity coefficients and the thermodynamic factors, FT, have been estimated. Within experimental error, the hydrodynamic volume calculated from this is identical to the molar volume obtained from density measurements. From the NMR spectra and literature data, it is suggested that this amino acid diffuses in aqueous solution as a curved, coil-like hydrated zwitterionic entity.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-04-29T20:53:28Z
2020-04-29T20:53:28Z
dc.type.none.fl_str_mv Artículo
info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/article
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://dx.doi.org/10.1016/j.jct.2016.09.014
http://hdl.handle.net/20.500.12010/9083
http://dx.doi.org/10.1016/j.jct.2016.09.014
instname:Universidad de Bogotá Jorge Tadeo Lozano
reponame:Repositorio Institucional de la Universidad de Bogotá Jorge Tadeo Lozano
url http://dx.doi.org/10.1016/j.jct.2016.09.014
http://hdl.handle.net/20.500.12010/9083
identifier_str_mv instname:Universidad de Bogotá Jorge Tadeo Lozano
reponame:Repositorio Institucional de la Universidad de Bogotá Jorge Tadeo Lozano
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Abierto (Texto Completo)
eu_rights_str_mv openAccess
rights_invalid_str_mv Abierto (Texto Completo)
dc.format.none.fl_str_mv 40 páginas
image/jepg
image/png
application/pdf
dc.coverage.none.fl_str_mv Bogotá, Colombia
dc.publisher.none.fl_str_mv Universidad de Bogotá Jorge Tadeo Lozano
publisher.none.fl_str_mv Universidad de Bogotá Jorge Tadeo Lozano
dc.source.none.fl_str_mv reponame:Expeditio: repositorio UTadeo
instname:Universidad de Bogotá Jorge Tadeo Lozano
instacron:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
instacron_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio: repositorio UTadeo
collection Expeditio: repositorio UTadeo
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score 15,811543

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