Evaluation of a Cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia
A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Crypto...
| Authors: | , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2017 |
| Country: | Colombia |
| Institution: | Universidad del Rosario |
| Repository: | Repositorio EdocUR - U. Rosario |
| Language: | English |
| OAI Identifier: | oai:repository.urosario.edu.co:10336/21972 |
| Online Access: | https://doi.org/10.1590/S1678-9946201759076 https://repository.urosario.edu.co/handle/10336/21972 |
| Access Level: | Open access |
| Keyword: | Enfermedades Article Human Cryptococcosis Cryptococcus Antigen Diagnosis Point-of-care Lateral Flow Assay Immunochromatographic assay Latex agglutination system |
| Summary: | A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. |
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