Mucormycosis (Zygomycosis) in a heart-Kidney trasplant recipient : recovery after posaconazole therapy
ABSTRACT: We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) the...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2003 |
| País: | Colombia |
| Institución: | Universidad de Antioquia |
| Repositorio: | Repositorio UdeA |
| Idioma: | inglés |
| OAI Identifier: | oai:bibliotecadigital.udea.edu.co:10495/24085 |
| Acceso en línea: | http://hdl.handle.net/10495/24085 |
| Access Level: | acceso abierto |
| Palabra clave: | Diabetes mellitus Trasplante de Riñón Kidney Transplantation Zigomicosis Zygomycosis Anfotericina B Amphotericin B Mucormicosis Mucormycosis Rhizopus Ácido Desoxicólico Deoxycholic Acid Receptores de Trasplantes Transplant Recipients Riñón Kidney Corazón Heart Inmunosupresión Inmunosuppression |
| Sumario: | ABSTRACT: We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events. |
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