Changes in selenium levels in epilepsy
Introduction. It has been suggested that antiepileptic drug therapies deplete total body selenium stores and failure to give appropriate selenium supplementation, especially to patients receiving valproic acid during pregnancy may increase the risk of neural tube defects or other free radical mediat...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Colombia |
| Institución: | Universidad del Rosario |
| Repositorio: | Repositorio EdocUR - U. Rosario |
| Idioma: | inglés |
| OAI Identifier: | oai:repository.urosario.edu.co:10336/23128 |
| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/23128 |
| Access Level: | acceso abierto |
| Palabra clave: | Anticonvulsive agent Free radical Glutathione peroxidase Selenium Selenoprotein Valproic acid Protein Behavior Data base Epilepsy Human Medical literature Medical research Neural tube defect Practice guideline Pregnancy Protein synthesis Review Vitamin supplementation Bibliographic database Blood Degenerative disease Diet supplementation Female Metabolism Oxidative stress Anticonvulsants Dietary supplements Humans Neurodegenerative diseases Proteins Selenoproteins Evidence-based medicine Trace elements bibliographic Databases |
| Sumario: | Introduction. It has been suggested that antiepileptic drug therapies deplete total body selenium stores and failure to give appropriate selenium supplementation, especially to patients receiving valproic acid during pregnancy may increase the risk of neural tube defects or other free radical mediated damage. Selenium is essential for the synthesis of selenoproteins, including glutathione peroxidase. Aims. To review the present state of knowledge about selenium behaviour in people with epilepsy taking antiepileptic drugs and to develop guidelines for the appropriate use of selenium supplements. Development. Databases such as Medline, Embase, Scisearch and Lilacs were consulted to have access to literature. A search in said databases was performed in order to find articles published from January 1966 to August 2004. All articles published in English and Spanish were considered. A manual review of the references present in each produced article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles which seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. There is insufficient evidence to fully evaluate the effect of selenium supplementation. The possible beneficial effects on pregnancy need to be evaluated in further studies. © 2005, Revista de Neurología. |
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