Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection

ABSTARCT: During HIV infection, specific responses exhibited by CD8+ T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8+ T cells subsets have been identified, exhibiting differences in terms of ac...

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Detalles Bibliográficos
Autores: González Díaz, Sandra Milena, Taborda Vanegas, Natalia Andrea, Rugeles López, María Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Colombia
Institución:Universidad de Antioquia
Repositorio:Repositorio UdeA
Idioma:inglés
OAI Identifier:oai:bibliotecadigital.udea.edu.co:10495/11509
Acceso en línea:http://hdl.handle.net/10495/11509
Access Level:acceso abierto
Palabra clave:Antiviral immune response
HIV infection
Resistance to HIV
HIV control
CD8+ T cells
Human immunodeficiency viruses
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spelling Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and InfectionGonzález Díaz, Sandra MilenaTaborda Vanegas, Natalia AndreaRugeles López, María TeresaAntiviral immune responseHIV infectionResistance to HIVHIV controlCD8+ T cellsHuman immunodeficiency virusesABSTARCT: During HIV infection, specific responses exhibited by CD8+ T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8+ T cells subsets have been identified, exhibiting differences in terms of activation, functional profile, and ability to limit HIV replication. Some of the most important CD8+ T cells subsets associated with viral control, production of potent antiviral molecules, and strong polyfunctional responses include Th1-like cytokine pattern and Tc17 cells. In addition, the expression of specific activation markers has been also associated with a more effective response of CD8+ T cells, as evidenced in HLA-DR+ CD38- cells. CD8+ T cells in both, peripheral blood and gut mucosa, are particularly important in individuals with a resistant phenotype, including HIV-exposed seronegative individuals (HESNs), long-term non-progressors (LTNPs) and HIV-controllers. Although the role of CD8+ T cells has been extensively explored in the context of an established HIV-1 infection, the presence of HIV-specific cells with effector abilities and a defined functional profile in HESNs, remain poorly understood. Here, we reviewed studies carried out on different subpopulations of CD8+ T cells in relation with natural resistance to HIV infection and progression. Keywords: CD8+ T cells subpopulations, HIV infection, Natural resistance to HIV, spontaneous control of HIV replication, antiviral immune responseFrontiers Research FoundationInmunovirologíaSuiza2019-07-23T21:28:19Z2019-07-23T21:28:19Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigación8application/pdfapplication/pdfGonzalez SM, Taborda NA, Rugeles MT. Role of Different Subpopulations of CD8(+) T Cells during HIV Exposure and Infection. Front Immunol. 2017 Aug 7;8:936. DOI: 10.3389/fimmu1664-3224http://hdl.handle.net/10495/1150910.3389/fimmu.2017.00936engFront ImmunolAtribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/reponame:Repositorio UdeAinstname:Universidad de Antioquiainstacron:Universidad de Antioquia2021-03-25T02:05:48Z
dc.title.none.fl_str_mv Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
title Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
spellingShingle Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
González Díaz, Sandra Milena
Antiviral immune response
HIV infection
Resistance to HIV
HIV control
CD8+ T cells
Human immunodeficiency viruses
title_short Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
title_full Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
title_fullStr Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
title_full_unstemmed Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
title_sort Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
dc.creator.none.fl_str_mv González Díaz, Sandra Milena
Taborda Vanegas, Natalia Andrea
Rugeles López, María Teresa
author González Díaz, Sandra Milena
author_facet González Díaz, Sandra Milena
Taborda Vanegas, Natalia Andrea
Rugeles López, María Teresa
author_role author
author2 Taborda Vanegas, Natalia Andrea
Rugeles López, María Teresa
author2_role author
author
dc.subject.none.fl_str_mv Antiviral immune response
HIV infection
Resistance to HIV
HIV control
CD8+ T cells
Human immunodeficiency viruses
topic Antiviral immune response
HIV infection
Resistance to HIV
HIV control
CD8+ T cells
Human immunodeficiency viruses
description ABSTARCT: During HIV infection, specific responses exhibited by CD8+ T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8+ T cells subsets have been identified, exhibiting differences in terms of activation, functional profile, and ability to limit HIV replication. Some of the most important CD8+ T cells subsets associated with viral control, production of potent antiviral molecules, and strong polyfunctional responses include Th1-like cytokine pattern and Tc17 cells. In addition, the expression of specific activation markers has been also associated with a more effective response of CD8+ T cells, as evidenced in HLA-DR+ CD38- cells. CD8+ T cells in both, peripheral blood and gut mucosa, are particularly important in individuals with a resistant phenotype, including HIV-exposed seronegative individuals (HESNs), long-term non-progressors (LTNPs) and HIV-controllers. Although the role of CD8+ T cells has been extensively explored in the context of an established HIV-1 infection, the presence of HIV-specific cells with effector abilities and a defined functional profile in HESNs, remain poorly understood. Here, we reviewed studies carried out on different subpopulations of CD8+ T cells in relation with natural resistance to HIV infection and progression. Keywords: CD8+ T cells subpopulations, HIV infection, Natural resistance to HIV, spontaneous control of HIV replication, antiviral immune response
publishDate 2017
dc.date.none.fl_str_mv 2017
2019-07-23T21:28:19Z
2019-07-23T21:28:19Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_2df8fbb1
https://purl.org/redcol/resource_type/ART
Artículo de investigación
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Gonzalez SM, Taborda NA, Rugeles MT. Role of Different Subpopulations of CD8(+) T Cells during HIV Exposure and Infection. Front Immunol. 2017 Aug 7;8:936. DOI: 10.3389/fimmu
1664-3224
http://hdl.handle.net/10495/11509
10.3389/fimmu.2017.00936
identifier_str_mv Gonzalez SM, Taborda NA, Rugeles MT. Role of Different Subpopulations of CD8(+) T Cells during HIV Exposure and Infection. Front Immunol. 2017 Aug 7;8:936. DOI: 10.3389/fimmu
1664-3224
10.3389/fimmu.2017.00936
url http://hdl.handle.net/10495/11509
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol
dc.rights.none.fl_str_mv Atribución 2.5
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv Atribución 2.5
http://creativecommons.org/licenses/by/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
Inmunovirología
Suiza
publisher.none.fl_str_mv Frontiers Research Foundation
Inmunovirología
Suiza
dc.source.none.fl_str_mv reponame:Repositorio UdeA
instname:Universidad de Antioquia
instacron:Universidad de Antioquia
instname_str Universidad de Antioquia
instacron_str Universidad de Antioquia
institution Universidad de Antioquia
reponame_str Repositorio UdeA
collection Repositorio UdeA
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score 15,812429

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