Furan type lignans with antimycobacterial activity
ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Colombia |
| Institución: | Universidad de Antioquia |
| Repositorio: | Repositorio UdeA |
| Idioma: | inglés |
| OAI Identifier: | oai:bibliotecadigital.udea.edu.co:10495/22184 |
| Acceso en línea: | http://hdl.handle.net/10495/22184 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-Bacterial Agents Antibacterianos Lignans Lignanas Tuberculosis Bioassays Ensayo biológico Arylfuran http://aims.fao.org/aos/agrovoc/c_36421 http://aims.fao.org/aos/agrovoc/c_7997 http://aims.fao.org/aos/agrovoc/c_15731 |
| Sumario: | ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied plants known with this type of lignans, as potential active against Mycobacterium tuberculosis. Fractions of the active extracts were tested for anti-TB activity and their chemical constituents analyzed by NMR spectroscopy. Several extracts and chromatographical fractions exhibited > 90% inhibition of M. tuberculosis at 128 ug/mL. Methylpluviatilol, a pure compound isolated from Virola sebifera, was active at this concentration. These findings suggest that plant species of the families here studied may yield novel lead compounds for the development of antimycobacterial agents. |
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