Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.

Objective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cros...

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Authors: Ruiz-Garzon, Jair Antonio, Rojas-Velandia, Camilo Andrés, Calderón Ospina, Carlos Alberto
Format: article
Status:Published version
Publication Date:2019
Country:Colombia
Institution:Universidad del Rosario
Repository:Repositorio EdocUR - U. Rosario
Language:English
OAI Identifier:oai:repository.urosario.edu.co:10336/24647
Online Access:https://doi.org/10.4103/jrpp.jrpp_18_69
https://repository.urosario.edu.co/handle/10336/24647
Access Level:Open access
Keyword:Drug-related side effects and adverse reactions
intensive care units
patient admissions
pharmacovigilance
postmarketing
product surveillance
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spelling Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.Ruiz-Garzon, Jair AntonioRojas-Velandia, Camilo AndrésCalderón Ospina, Carlos AlbertoDrug-related side effects and adverse reactionsintensive care unitspatient admissionspharmacovigilancepostmarketingproduct surveillanceObjective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cross-sectional observational study. Clinical records of patients who arrived at the emergency service of a third-care level university hospital were reviewed. Information was collected by a resident in clinical toxicology, and each case was validated and analyzed by a research team using the algorithm proposed by Vaca Gonzalez and Schumock and Thornton criteria for preventability to evaluate the existence of possible medication errors. Findings: In total, 697 clinical records were evaluated and 18 patients presented TFs (2.6%, 95% confidence interval 1.5%-4.1%) as the cause of admission to the ICU. The most frequent TFs were seizures (56%) and hypertension (28%). The most commonly associated medications were valproic acid (28%) and losartan (28%). Ten cases (56%) were associated with drug misuse and the same number of cases was preventable, according to Schumock and Thornton criteria. Conclusion: This is the first study assessing TFs as a cause of admission to the ICU in the Colombian population. The frequency of TFs in our study was similar to that described in the literature; being the most common cause the inappropriate drug use, particularly for drugs with complex kinetics, such as antiepileptic drugs.Journal of Research in Pharmacy Practice20192020-06-11T13:20:57Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.4103/jrpp.jrpp_18_692319-96442279-042Xhttps://repository.urosario.edu.co/handle/10336/24647reponame:Repositorio EdocUR - U. Rosarioinstname:Universidad del Rosarioinstacron:Universidad del Rosarioenghttps://doi.org/10.4103/jrpp.jrpp_18_69info:eu-repo/semantics/openAccess2022-05-02T07:37:16Z
dc.title.none.fl_str_mv Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
title Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
spellingShingle Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
Ruiz-Garzon, Jair Antonio
Drug-related side effects and adverse reactions
intensive care units
patient admissions
pharmacovigilance
postmarketing
product surveillance
title_short Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
title_full Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
title_fullStr Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
title_full_unstemmed Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
title_sort Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.
dc.creator.none.fl_str_mv Ruiz-Garzon, Jair Antonio
Rojas-Velandia, Camilo Andrés
Calderón Ospina, Carlos Alberto
author Ruiz-Garzon, Jair Antonio
author_facet Ruiz-Garzon, Jair Antonio
Rojas-Velandia, Camilo Andrés
Calderón Ospina, Carlos Alberto
author_role author
author2 Rojas-Velandia, Camilo Andrés
Calderón Ospina, Carlos Alberto
author2_role author
author
dc.subject.none.fl_str_mv Drug-related side effects and adverse reactions
intensive care units
patient admissions
pharmacovigilance
postmarketing
product surveillance
topic Drug-related side effects and adverse reactions
intensive care units
patient admissions
pharmacovigilance
postmarketing
product surveillance
description Objective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cross-sectional observational study. Clinical records of patients who arrived at the emergency service of a third-care level university hospital were reviewed. Information was collected by a resident in clinical toxicology, and each case was validated and analyzed by a research team using the algorithm proposed by Vaca Gonzalez and Schumock and Thornton criteria for preventability to evaluate the existence of possible medication errors. Findings: In total, 697 clinical records were evaluated and 18 patients presented TFs (2.6%, 95% confidence interval 1.5%-4.1%) as the cause of admission to the ICU. The most frequent TFs were seizures (56%) and hypertension (28%). The most commonly associated medications were valproic acid (28%) and losartan (28%). Ten cases (56%) were associated with drug misuse and the same number of cases was preventable, according to Schumock and Thornton criteria. Conclusion: This is the first study assessing TFs as a cause of admission to the ICU in the Colombian population. The frequency of TFs in our study was similar to that described in the literature; being the most common cause the inappropriate drug use, particularly for drugs with complex kinetics, such as antiepileptic drugs.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020-06-11T13:20:57Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.4103/jrpp.jrpp_18_69
2319-9644
2279-042X
https://repository.urosario.edu.co/handle/10336/24647
url https://doi.org/10.4103/jrpp.jrpp_18_69
https://repository.urosario.edu.co/handle/10336/24647
identifier_str_mv 2319-9644
2279-042X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://doi.org/10.4103/jrpp.jrpp_18_69
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Research in Pharmacy Practice
publisher.none.fl_str_mv Journal of Research in Pharmacy Practice
dc.source.none.fl_str_mv reponame:Repositorio EdocUR - U. Rosario
instname:Universidad del Rosario
instacron:Universidad del Rosario
instname_str Universidad del Rosario
instacron_str Universidad del Rosario
institution Universidad del Rosario
reponame_str Repositorio EdocUR - U. Rosario
collection Repositorio EdocUR - U. Rosario
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score 15.198674

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