Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both...
| Authors: | , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2017 |
| Country: | Colombia |
| Institution: | Universidad Nacional de Colombia |
| Repository: | Repositorio UN |
| Language: | Spanish |
| OAI Identifier: | oai:repositorio.unal.edu.co:unal/66260 |
| Online Access: | https://repositorio.unal.edu.co/handle/unal/66260 http://bdigital.unal.edu.co/67284/ |
| Access Level: | Open access |
| Keyword: | 54 Química y ciencias afines / Chemistry Evernia prunastri condensation reaction TEMA MIC. reacción de condensación MIC |
| Summary: | Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively. |
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