Nefrotoxicidad inducida por medicamentos
Drug-induced nephrotoxicityThis review includes a description of the different types of drug-induced nephrotoxicity (DIN) according to histopathologicclassification, generation mechanism, clinical presentation and drugs most frequently involved. For this review, a systematicsearch was con...
| Autores: | , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2011 |
| País: | Colombia |
| Recursos: | Universidad Industrial de Santander |
| Repositório: | Repositorio UIS |
| Idioma: | espanhol |
| OAI Identifier: | oai:noesis.uis.edu.co:20.500.14071/5649 |
| Acesso em linha: | https://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/2583 https://noesis.uis.edu.co/handle/20.500.14071/5649 |
| Access Level: | Acceso aberto |
| Resumo: | Drug-induced nephrotoxicityThis review includes a description of the different types of drug-induced nephrotoxicity (DIN) according to histopathologicclassification, generation mechanism, clinical presentation and drugs most frequently involved. For this review, a systematicsearch was conducted in the Index Medicus for articles published since 1999, which were selected according to their relevance.The DIN is a finding of major clinical importance due to their high frequency and potential severity, and the lack of preventivemeasures in many cases. The main renal impairments caused by drugs can be classified histopathologically according toaltered renal function. Thus, there is the acute tubular necrosis, interstitial nephritis, glomerular injury and vascular changesthat in turn include thrombotic microangiopathy, atherosclerosis and vasculitis. Finally, some commonly used drugs with highpotential for nephrotoxicity are reviewed, with emphasis on recommendations for clinical use to optimize the renal safety ofthese products. Key words: Drug toxicity. Kidney. Acute renal injury. Chronic renal insufficiency. Medicamentous disease. Secondary effect. |
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