Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both access...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Colombia |
| Institución: | Universidad del Rosario |
| Repositorio: | Repositorio EdocUR - U. Rosario |
| Idioma: | inglés |
| OAI Identifier: | oai:repository.urosario.edu.co:10336/24294 |
| Acceso en línea: | https://doi.org/10.1016/j.meegid.2010.12.002 https://repository.urosario.edu.co/handle/10336/24294 |
| Access Level: | acceso abierto |
| Palabra clave: | Membrane protein Merozoite surface protein 10 Merozoite surface protein 7a Merozoite surface protein 7k Unclassified drug Article Colombia Controlled study Genetic conservation Genetic polymorphism Genetic variability Geography Haplotype Nonhuman Nucleotide sequence Plasmodium vivax Priority journal Genetic variation Genotype Host-parasite interactions Humans Malaria vaccines Membrane proteins Molecular sequence data Polymerase chain reaction Protozoan proteins Merozoite surface protein P Vivax Vaccine candidate protozoan genetic vivax Antigens Malaria Polymorphism |
| Sumario: | The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V. |
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