ARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniae

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) in...

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Detalhes bibliográficos
Autores: Jacobs, Michael R., Good, Caryn E., Hujer, Andrea M., Abdelhamed, Ayman M., Rhoads, Daniel, Hujer, Kristine M., Rudin, Susan D., Domitrovic, T. Nicholas J., Connolly, Lynn E., Krause, Kevin M., Patel, Robin, Arias, Cesar A, Kreiswirth, Barry N., Rojas, Laura J., D'Souza, Roshan, King, C. Richard, Brinkac, Lauren M., Nguyen, Kevin, Singh, Indresh, Fouts, Derrick E., van Duin, David, Bonomo, Robert A.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:Colombia
Recursos:Universidad El Bosque
Repositório:Repositorio U. El Bosque
Idioma:inglês
OAI Identifier:oai:repositorio.unbosque.edu.co:20.500.12495/3501
Acesso em linha:http://hdl.handle.net/20.500.12495/3501
https://doi.org/10.1128/aac.00012-20
https://repositorio.unbosque.edu.co
Access Level:Acceso aberto
Palavra-chave:Enterobacteriaceae resistentes a los carbapenémicos
Carbapenémicos
Proteínas asociadas a resistencia a múltiples medicamentos
Klebsiella
Antibiotic resistance
Carbapenemase
Descrição
Resumo:Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.

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