Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus

The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding affinities and intracellular sig

Detalles Bibliográficos
Autores: Westermeier, F, Saez, T, Arroyo, P, Toledo, F, Gutierrez, J, Sanhueza, C, Pardo, F, Leiva, A, Sobrevia, L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/232667
Acceso en línea:https://hdl.handle.net/10533/232667
Access Level:acceso abierto
Descripción
Sumario:The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding affinities and intracellular sig