Charged residues at the first transmembrane region contribute to the voltage dependence of the slow gate of connexins

Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channels and hemichannels. Connexin-based channels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating. Residues located at the C terminus o

Detalles Bibliográficos
Autores: Pinto, Bernardo I, Garcia, Isaac E, Pupo, Amaury, Retamal, Mauricio A, Martinez, Agustin D, Latorre, Ramon, Gonzalez, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/231944
Acceso en línea:https://hdl.handle.net/10533/231944
Access Level:acceso abierto
Descripción
Sumario:Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channels and hemichannels. Connexin-based channels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating. Residues located at the C terminus o