CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING

Caveolin-1 is a member of the caveolin family of proteins that are implicated in caveolae morphogenesis, cholesterol homeostasis, and regulation of a plethora of signaling pathways. Moreover, this isoform, in particular, is suggested to function as a regulator of tumor development and progression. S...

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Detalles Bibliográficos
Autores: Gutierrez Pajares, Jorge Luis, Quest Minikus, Andrew Frederick Geoffery, Rodriguez Gonzalez, Diego Alejandro, Tapia Pineda, Julio Cesar, Torres Gomez, Vicente Armando
Tipo de recurso: capítulo de libro
Estado:Versión publicada
Fecha de publicación:2012
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/164348
Acceso en línea:https://hdl.handle.net/10533/164348
Access Level:acceso abierto
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spelling Torres Gomez, Vicente ArmandoTapia Pineda, Julio CesarRodriguez Gonzalez, Diego AlejandroQuest Minikus, Andrew Frederick GeofferyGutierrez Pajares, Jorge Luis201210.1007/978-1-4614-1001-0https://hdl.handle.net/10533/164348http://purl.org/coar/access_right/c_abf2CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING4117ALEMANIAGutierrez Pajares, Jorge LuisQuest Minikus, Andrew Frederick GeofferyRodriguez Gonzalez, Diego AlejandroTapia Pineda, Julio CesarTorres Gomez, Vicente ArmandoJasmin, Jean FrancoisLisanti, Michael PMercier, Isabelle2016-12-27T21:46:40Z2022-06-17T21:03:43Z2016-12-27T21:46:40Z2022-06-17T21:03:43Z2012Caveolin-1 is a member of the caveolin family of proteins that are implicated in caveolae morphogenesis, cholesterol homeostasis, and regulation of a plethora of signaling pathways. Moreover, this isoform, in particular, is suggested to function as a regulator of tumor development and progression. Since caveolin-1 inhibits many signaling pathways that favor cell proliferation and reduce cell death, caveolin-1 was ascribed the role of a tumor suppressor. Insights from studies in knock-out mice favor this interpretation, since caveolin-1 absence augments “tumor susceptibility,” that is tumor development in specific experimental settings occurs more readily in these animals. However, an alternative, opposite view is also provided by data available in the literature, indicating that caveolin-1 promotes tumorigenesis and is associated with phenomena like multidrug resistance, enhanced invasiveness, and metastasis. Indeed, in certain human cancers, caveolin-1 expression correlates with poor patient prognosis and decreased survival. Hence, the role that caveolin-1 plays in cancer is currently a matter of intense debate. Here, the discussion will focus on this “ambiguity” of caveolin-1 function in the context of colon cancer. Alterations in canonical Wnt signaling and ?-catenin-Tcf/Lef-dependent transcription are frequently associated with the development of this disease. Evidence indicating how the presence of caveolin-1 inhibits signaling through this pathway, as well as how the ability of caveolin-1 to do so is modulated both by intracellular and extracellular conditions will be discussed. Finally, a model based on the events described in colon cancer cells will be developed to summarize events considered relevant to caveolin-1 function as a “conditional” tumor suppressor.FONDECYT123FONDECYT1090071978-1-4614-1000-3978-1-4614-1001-0https://hdl.handle.net/10533/164348engSPRINGERinstname: Conicytreponame: Repositorio Digital RI2.0instname: Conicytreponame: Repositorio Digital RI 2.010.1007/978-1-4614-1001-0info:eu-repo/grantAgreement/Fondecyt/1090071info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479http://download.springer.com/static/pdf/661/bfm%253A978-1-4614-1001-0%252F1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Fbook%2Fbfm%3A978-1-4614-1001-0%2F1&token2=exp=1466020148~acl=%2Fstatic%2Fpdf%2F661%2Fbfm%25253A978-1-4614-1001-0%25252F1.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Fbook%252Fbfm%253A978-1-4614-1001-0%252F1*~hmac=10eb245ffe1cc3c51ed3942030f5eeb891d85372d3b252af4bd65a687c07b20einfo:eu-repo/semantics/openAccessCAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLINGCAVEOLINS IN CANCER PATHOGENESIS, PREVENTION AND THERAPYCapitulo de libroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPartCapituloLibrohttps://hdl.handle.net/10533/164348FONDECYThttp://purl.org/coar/resource_type/c_32485270dc0c-b664-4807-9a89-8156691b8436virtual::74615-15270dc0c-b664-4807-9a89-8156691b8436virtual::74615-110533/164348oai:repositorio.anid.cl:10533/1643482023-07-03 23:30:13.819https://repositorio.anid.clRepositorio ANIDaletelier@anid.cl
dc.title.none.fl_str_mv CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
dc.title.libro.none.fl_str_mv CAVEOLINS IN CANCER PATHOGENESIS, PREVENTION AND THERAPY
title CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
spellingShingle CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
Gutierrez Pajares, Jorge Luis
title_short CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
title_full CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
title_fullStr CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
title_full_unstemmed CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
title_sort CAVEOLIN-1 IN COLON CANCER: THE FLEXIBLE CONNECTION TO WNT SIGNALLING
dc.creator.none.fl_str_mv Gutierrez Pajares, Jorge Luis
Quest Minikus, Andrew Frederick Geoffery
Rodriguez Gonzalez, Diego Alejandro
Tapia Pineda, Julio Cesar
Torres Gomez, Vicente Armando
dc.creator.libro.none.fl_str_mv Jasmin, Jean Francois
Lisanti, Michael P
Mercier, Isabelle
author Gutierrez Pajares, Jorge Luis
author_facet Gutierrez Pajares, Jorge Luis
Quest Minikus, Andrew Frederick Geoffery
Rodriguez Gonzalez, Diego Alejandro
Tapia Pineda, Julio Cesar
Torres Gomez, Vicente Armando
author_role author
author2 Quest Minikus, Andrew Frederick Geoffery
Rodriguez Gonzalez, Diego Alejandro
Tapia Pineda, Julio Cesar
Torres Gomez, Vicente Armando
author2_role author
author
author
author
description Caveolin-1 is a member of the caveolin family of proteins that are implicated in caveolae morphogenesis, cholesterol homeostasis, and regulation of a plethora of signaling pathways. Moreover, this isoform, in particular, is suggested to function as a regulator of tumor development and progression. Since caveolin-1 inhibits many signaling pathways that favor cell proliferation and reduce cell death, caveolin-1 was ascribed the role of a tumor suppressor. Insights from studies in knock-out mice favor this interpretation, since caveolin-1 absence augments “tumor susceptibility,” that is tumor development in specific experimental settings occurs more readily in these animals. However, an alternative, opposite view is also provided by data available in the literature, indicating that caveolin-1 promotes tumorigenesis and is associated with phenomena like multidrug resistance, enhanced invasiveness, and metastasis. Indeed, in certain human cancers, caveolin-1 expression correlates with poor patient prognosis and decreased survival. Hence, the role that caveolin-1 plays in cancer is currently a matter of intense debate. Here, the discussion will focus on this “ambiguity” of caveolin-1 function in the context of colon cancer. Alterations in canonical Wnt signaling and ?-catenin-Tcf/Lef-dependent transcription are frequently associated with the development of this disease. Evidence indicating how the presence of caveolin-1 inhibits signaling through this pathway, as well as how the ability of caveolin-1 to do so is modulated both by intracellular and extracellular conditions will be discussed. Finally, a model based on the events described in colon cancer cells will be developed to summarize events considered relevant to caveolin-1 function as a “conditional” tumor suppressor.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2016-12-27T21:46:40Z
2022-06-17T21:03:43Z
dc.date.available.none.fl_str_mv 2016-12-27T21:46:40Z
2022-06-17T21:03:43Z
dc.type.none.fl_str_mv Capitulo de libro
info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.folio.none.fl_str_mv 1090071
dc.identifier.isbn.none.fl_str_mv 978-1-4614-1000-3
978-1-4614-1001-0
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10533/164348
identifier_str_mv 1090071
978-1-4614-1000-3
978-1-4614-1001-0
url https://hdl.handle.net/10533/164348
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv instname: Conicyt
reponame: Repositorio Digital RI2.0
instname: Conicyt
reponame: Repositorio Digital RI 2.0
dc.relation.doi.none.fl_str_mv 10.1007/978-1-4614-1001-0
dc.relation.projectid.none.fl_str_mv info:eu-repo/grantAgreement/Fondecyt/1090071
dc.relation.set.none.fl_str_mv info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.relation.uri.none.fl_str_mv http://download.springer.com/static/pdf/661/bfm%253A978-1-4614-1001-0%252F1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Fbook%2Fbfm%3A978-1-4614-1001-0%2F1&token2=exp=1466020148~acl=%2Fstatic%2Fpdf%2F661%2Fbfm%25253A978-1-4614-1001-0%25252F1.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Fbook%252Fbfm%253A978-1-4614-1001-0%252F1*~hmac=10eb245ffe1cc3c51ed3942030f5eeb891d85372d3b252af4bd65a687c07b20e
dc.rights.driver.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.editorial.none.fl_str_mv SPRINGER
repository.name.fl_str_mv Repositorio ANID
repository.mail.fl_str_mv aletelier@anid.cl
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score 15,812429

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