ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA

The systemic ventilatory and cardiovascular adjustments to hypoxia depend on the activation of peripheral chemoreceptors, mainly the carotid bodies (CBs). Intermittent hypoxia produces CB chemosensory excitation, which may participate in the pathogenesis of obstructive sleep apnea (OSA) (Narkiewicz...

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Detalles Bibliográficos
Autores: Del Rio Troncoso, Rodrigo Andre, Iturriaga Aguera, Rodrigo Manuel, Rey Keim, Sergio
Tipo de recurso: capítulo de libro
Estado:Versión publicada
Fecha de publicación:2006
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/165576
Acceso en línea:https://hdl.handle.net/10533/165576
Access Level:acceso abierto
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spelling Rey Keim, SergioIturriaga Aguera, Rodrigo ManuelDel Rio Troncoso, Rodrigo Andre2006https://hdl.handle.net/10533/165576http://purl.org/coar/access_right/c_abf2ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA350345ESTADOS UNIDOS DE AMERICANEW YORKDel Rio Troncoso, Rodrigo AndreIturriaga Aguera, Rodrigo ManuelRey Keim, SergioGonzalez, ConstancioHayashida, YoshiakiKondo, Hisatake2016-12-27T21:50:29Z2022-06-17T20:37:39Z2016-12-27T21:50:29Z2022-06-17T20:37:39Z2006The systemic ventilatory and cardiovascular adjustments to hypoxia depend on the activation of peripheral chemoreceptors, mainly the carotid bodies (CBs). Intermittent hypoxia produces CB chemosensory excitation, which may participate in the pathogenesis of obstructive sleep apnea (OSA) (Narkiewicz et al., 1999). Recently, we found that chronic intermittent hypoxia (CIH) for four days enhances cat ventilatory and chemosensory responses to acute hypoxia (Rey et al., 2004). We hypothesized that the enhanced chemosensory response to hypoxia induced by CIH would be the result of an increased effect of excitatory modulators, like endothelin (ETs) peptides, and/or a decreased effect of inhibitory molecules within the CB. Thus, we studied the contribution of ETs on the enhanced chemosensory response to hypoxia in CIH-treated cats.FONDECYT0FONDECYT10303300-387-31310-9 https://hdl.handle.net/10533/165576engSPRINGERinstname: Conicytreponame: Repositorio Digital RI2.0instname: Conicytreponame: Repositorio Digital RI 2.0ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGYinfo:eu-repo/grantAgreement/Fondecyt/1030330info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479info:eu-repo/semantics/openAccessROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIATHE ARTERIAL CHEMORECEPTORSCapitulo de libroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPartCapituloLibrohttps://hdl.handle.net/10533/165576FONDECYThttp://purl.org/coar/resource_type/c_32488f0ad49f-d679-41f6-a11d-9f44c8e34078virtual::13323-18f0ad49f-d679-41f6-a11d-9f44c8e34078virtual::13323-110533/165576oai:repositorio.anid.cl:10533/1655762023-07-04 00:30:07.303https://repositorio.anid.clRepositorio ANIDaletelier@anid.cl
dc.title.none.fl_str_mv ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
dc.title.libro.none.fl_str_mv THE ARTERIAL CHEMORECEPTORS
title ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
spellingShingle ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
Del Rio Troncoso, Rodrigo Andre
title_short ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
title_full ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
title_fullStr ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
title_full_unstemmed ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
title_sort ROLE OF ENDOTHELIN-1 ON THE ENHANCED CAROTID BODY ACTIVITY INDUCED BY CHRONIC INTERMITTENT HYPOXIA
dc.creator.none.fl_str_mv Del Rio Troncoso, Rodrigo Andre
Iturriaga Aguera, Rodrigo Manuel
Rey Keim, Sergio
dc.creator.libro.none.fl_str_mv Gonzalez, Constancio
Hayashida, Yoshiaki
Kondo, Hisatake
author Del Rio Troncoso, Rodrigo Andre
author_facet Del Rio Troncoso, Rodrigo Andre
Iturriaga Aguera, Rodrigo Manuel
Rey Keim, Sergio
author_role author
author2 Iturriaga Aguera, Rodrigo Manuel
Rey Keim, Sergio
author2_role author
author
description The systemic ventilatory and cardiovascular adjustments to hypoxia depend on the activation of peripheral chemoreceptors, mainly the carotid bodies (CBs). Intermittent hypoxia produces CB chemosensory excitation, which may participate in the pathogenesis of obstructive sleep apnea (OSA) (Narkiewicz et al., 1999). Recently, we found that chronic intermittent hypoxia (CIH) for four days enhances cat ventilatory and chemosensory responses to acute hypoxia (Rey et al., 2004). We hypothesized that the enhanced chemosensory response to hypoxia induced by CIH would be the result of an increased effect of excitatory modulators, like endothelin (ETs) peptides, and/or a decreased effect of inhibitory molecules within the CB. Thus, we studied the contribution of ETs on the enhanced chemosensory response to hypoxia in CIH-treated cats.
publishDate 2006
dc.date.issued.none.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2016-12-27T21:50:29Z
2022-06-17T20:37:39Z
dc.date.available.none.fl_str_mv 2016-12-27T21:50:29Z
2022-06-17T20:37:39Z
dc.type.none.fl_str_mv Capitulo de libro
info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.folio.none.fl_str_mv 1030330
dc.identifier.isbn.none.fl_str_mv 0-387-31310-9 
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10533/165576
identifier_str_mv 1030330
0-387-31310-9 
url https://hdl.handle.net/10533/165576
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv instname: Conicyt
reponame: Repositorio Digital RI2.0
instname: Conicyt
reponame: Repositorio Digital RI 2.0
dc.relation.ispartofseries.none.fl_str_mv ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
dc.relation.projectid.none.fl_str_mv info:eu-repo/grantAgreement/Fondecyt/1030330
dc.relation.set.none.fl_str_mv info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.rights.driver.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.coverage.spatial.none.fl_str_mv NEW YORK
dc.publisher.editorial.none.fl_str_mv SPRINGER
repository.name.fl_str_mv Repositorio ANID
repository.mail.fl_str_mv aletelier@anid.cl
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score 15.812429

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