Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process

Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of...

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Detalles Bibliográficos
Autor: Campos-Arteaga, Germán Adolfo
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2019
País:Chile
OAI Identifier:oai:repositorio.anid.cl:10533/236529
Acceso en línea:https://hdl.handle.net/10533/236529
Access Level:acceso abierto
Palabra clave:Ciencias Naturales
Otras Ciencias Naturales
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dc.title.es_CL.fl_str_mv Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
title Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
spellingShingle Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
Campos-Arteaga, Germán Adolfo
Ciencias Naturales
Otras Ciencias Naturales
title_short Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
title_full Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
title_fullStr Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
title_full_unstemmed Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
title_sort Neural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation Process
dc.creator.none.fl_str_mv Campos-Arteaga, Germán Adolfo
author Campos-Arteaga, Germán Adolfo
author_facet Campos-Arteaga, Germán Adolfo
author_role author
dc.contributor.advisor.none.fl_str_mv Rodríguez Balboa, Eugenio
dc.contributor.institution.es_CL.fl_str_mv UNIVERSIDAD CATOLICA
dc.subject.oecd1n.es_CL.fl_str_mv Ciencias Naturales
topic Ciencias Naturales
Otras Ciencias Naturales
dc.subject.oecd2n.es_CL.fl_str_mv Otras Ciencias Naturales
description Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns reflecting enhanced recollective processes during retrieval of reconsolidated memories. Moreover, we hypothesized that the administration of an amnesic agent during reconsolidation, such as a new learning, can reverse these neurophysiological changes. To test it, consolidated and reconsolidated declarative memories (and memories whose reconsolidation process was interfered) (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency of the parietal ERP old/new effect compared to memories that were consolidated or whose reconsolidation process was disrupted by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated to a late reversed mid-frontal effect. Complementarily, reactivated memories showed an earlier peak latency of the pupil old/new effect compared to nonreactivated memories. Based on these results, we argue that partially distinct brain mechanisms – presumably associated to enhanced recollective processes - support retrieval of reconsolidated declarative memories.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-08-28T21:25:36Z
2022-08-18T07:23:20Z
dc.date.available.none.fl_str_mv 2019-08-28T21:25:36Z
2022-08-18T07:23:20Z
dc.date.issued.es_CL.fl_str_mv 2019
dc.type.none.fl_str_mv Tesis Doctorado
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dc.type.tesis.none.fl_str_mv Tesis
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spelling UNIVERSIDAD CATOLICACampos-Arteaga, Germán Adolfo2019https://hdl.handle.net/10533/236529http://purl.org/coar/access_right/c_abf2Otras Ciencias NaturalesCiencias NaturalesNeural Correlates of Retrieval of Declarative Memories Modulated by the Reconsolidation ProcessRodríguez Balboa, EugenioUNIVERSIDAD CATOLICAChileCampos-Arteaga, Germán Adolfo2019-08-28T21:25:36Z2022-08-18T07:23:20Z2019-08-28T21:25:36Z2022-08-18T07:23:20Z2019Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns reflecting enhanced recollective processes during retrieval of reconsolidated memories. Moreover, we hypothesized that the administration of an amnesic agent during reconsolidation, such as a new learning, can reverse these neurophysiological changes. To test it, consolidated and reconsolidated declarative memories (and memories whose reconsolidation process was interfered) (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency of the parietal ERP old/new effect compared to memories that were consolidated or whose reconsolidation process was disrupted by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated to a late reversed mid-frontal effect. Complementarily, reactivated memories showed an earlier peak latency of the pupil old/new effect compared to nonreactivated memories. 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