Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids

We investigated herein: 1) the effects skeletal muscle disuse atrophy induced by two-week hind limb suspension (HS) on protein synthesis and degradation signaling in soleus muscle and the administration of either eicosapentaenoic (EPA) or docosahexaenoic (DHA)-rich fish oil supplementation, and 2) t...

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Detalles Bibliográficos
Autor: Marzuca-Nassr, Gabriel Nasri
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2017
País:Chile
OAI Identifier:oai:repositorio.anid.cl:10533/246530
Acceso en línea:https://hdl.handle.net/10533/246530
Access Level:acceso abierto
Palabra clave:Medicina y Ciencias de la Salud
Medicina Básica
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dc.title.es_CL.fl_str_mv Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
Vias de síntese e degradação de proteínas no músculo esquelético após atrofia por desuso: modulação por ácidos graxos ômega-3
title Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
spellingShingle Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
Marzuca-Nassr, Gabriel Nasri
Medicina y Ciencias de la Salud
Medicina Básica
title_short Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
title_full Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
title_fullStr Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
title_full_unstemmed Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
title_sort Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids
dc.creator.none.fl_str_mv Marzuca-Nassr, Gabriel Nasri
author Marzuca-Nassr, Gabriel Nasri
author_facet Marzuca-Nassr, Gabriel Nasri
author_role author
dc.contributor.advisor.none.fl_str_mv Curi, Rui
dc.contributor.institution.es_CL.fl_str_mv UNIVERSIDADE DE SAO PAULO
dc.subject.oecd1n.es_CL.fl_str_mv Medicina y Ciencias de la Salud
topic Medicina y Ciencias de la Salud
Medicina Básica
dc.subject.oecd2n.es_CL.fl_str_mv Medicina Básica
description We investigated herein: 1) the effects skeletal muscle disuse atrophy induced by two-week hind limb suspension (HS) on protein synthesis and degradation signaling in soleus muscle and the administration of either eicosapentaenoic (EPA) or docosahexaenoic (DHA)-rich fish oil supplementation, and 2) the changes induced by hind limb disuse on soleus muscle of Fat-1 transgenic mice. We concluded that, in spite of the small variation in the omega-6/omega-3 fatty acid ratio, significant effects of the increased omega-3 fatty acid levels were observed on the CSA and signaling pathways associated with soleus muscle protein synthesis and degradation in both experimental protocols.
publishDate 2017
dc.date.issued.es_CL.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-02-18T12:56:43Z
2022-08-16T16:46:48Z
dc.date.available.none.fl_str_mv 2021-02-18T12:56:43Z
2022-08-16T16:46:48Z
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spelling UNIVERSIDADE DE SAO PAULOMarzuca-Nassr, Gabriel Nasri2017https://hdl.handle.net/10533/246530http://purl.org/coar/access_right/c_abf2Medicina BásicaMedicina y Ciencias de la SaludProtein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acidsCuri, RuiUNIVERSIDADE DE SAO PAULOBrasilMarzuca-Nassr, Gabriel Nasri2021-02-18T12:56:43Z2022-08-16T16:46:48Z2021-02-18T12:56:43Z2022-08-16T16:46:48Z2017We investigated herein: 1) the effects skeletal muscle disuse atrophy induced by two-week hind limb suspension (HS) on protein synthesis and degradation signaling in soleus muscle and the administration of either eicosapentaenoic (EPA) or docosahexaenoic (DHA)-rich fish oil supplementation, and 2) the changes induced by hind limb disuse on soleus muscle of Fat-1 transgenic mice. We concluded that, in spite of the small variation in the omega-6/omega-3 fatty acid ratio, significant effects of the increased omega-3 fatty acid levels were observed on the CSA and signaling pathways associated with soleus muscle protein synthesis and degradation in both experimental protocols.Avaliamos no presente estudo: 1) os efeitos do desuso das patas traseiras de ratos por duas semanas sobre as vias de sinalização de síntese e degradação de proteínas no músculo sóleo e a administração de óleos de peixe ricos em eicosapentaenóico (EPA) ou docosaexaenóico (DHA) e 2) as alterações induzidas pelo desuso no músculo sóleo em camundongos FAT-1. Concluímos que, apesar da variação pequena na razão ácidos graxos ômega-6/ômega-3, efeitos significativos da oferta aumentada de ácidos graxos ômega-3 foram observados na área de seção transversa e vias de sinalização relacionadas à síntese e degradação de proteínas no músculo sóleo nos dois protocolos.72130103https://hdl.handle.net/10533/246530instname: Conicytreponame: Repositorio Digital RI2.0info:eu-repo/grantAgreement//72130103info:eu-repo/semantics/dataset/hdl.handle.net/10533/93488https://teses.usp.br/teses/disponiveis/42/42137/tde-10052017-105538/en.phpinfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 Chilehttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/Medicina y Ciencias de la SaludMedicina BásicaProtein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acidsVias de síntese e degradação de proteínas no músculo esquelético após atrofia por desuso: modulação por ácidos graxos ômega-3info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionTesisTesishttps://hdl.handle.net/10533/2465301ca32655-a6bc-4a3c-990c-1b2c7db108a9virtual::48809-11ca32655-a6bc-4a3c-990c-1b2c7db108a9virtual::48809-1THUMBNAILTESIS_GabrielNasriMarzucaNassr_Doutorado_I.pdf.jpgIM Thumbnailimage/jpeg4099https://repositorio.anid.cl/bitstreams/f7738110-b23d-4be3-9048-6633e685a9a5/download781c14d485f8035ac2073de0b2b44934MD51TEXTTESIS_GabrielNasriMarzucaNassr_Doutorado_I.pdf.txtExtracted texttext/plain243031https://repositorio.anid.cl/bitstreams/b8627a4f-a2fc-43d5-a0be-d1f4507e94af/download5a16e33ba70da43067c225da31fbdd30MD52CC-LICENSElicense_rdfapplication/octet-stream1232https://repositorio.anid.cl/bitstreams/f981d546-218a-4738-aa9d-e89ac39ebc2d/downloadf97bcfdf58f3e17b5cec231112dab5b1MD53LICENSElicense.txttext/plain1779https://repositorio.anid.cl/bitstreams/f6febf3e-ce1a-4711-a307-d56731d9eda9/download593a6e7305c66c56041a9f9e15a649c1MD54ORIGINALTESIS_GabrielNasriMarzucaNassr_Doutorado_I.pdfapplication/pdf5053018https://repositorio.anid.cl/bitstreams/b78c75d1-2f78-46bc-badc-9afd32029553/downloadb7bf8bc820ab727c6fff60dadc3dd737MD5510533/246530oai:repositorio.anid.cl:10533/2465302023-07-24 16:28:34.146http://creativecommons.org/licenses/by-nc-nd/3.0/cl/info:eu-repo/semantics/openAccesshttps://repositorio.anid.clRepositorio ANIDaletelier@anid.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