Modulation of Antiviral Immunity by Heme Oxygenase-1

Heme oxygenase-1 (H0-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide,...

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Authors: Espinoza, Janyra A, González-Muñoz, Pablo Alberto, Kalergis, Alexis M
Format: article
Status:Published version
Publication Date:2017
Country:Chile
Language:English
OAI Identifier:oai:repositorio.anid.cl:10533/220729
Online Access:https://hdl.handle.net/10533/220729
Access Level:Open access
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dc.title.es_CL.fl_str_mv Modulation of Antiviral Immunity by Heme Oxygenase-1
dc.title.journal.es_CL.fl_str_mv American Journal Of Pathology
title Modulation of Antiviral Immunity by Heme Oxygenase-1
spellingShingle Modulation of Antiviral Immunity by Heme Oxygenase-1
Espinoza, Janyra A
title_short Modulation of Antiviral Immunity by Heme Oxygenase-1
title_full Modulation of Antiviral Immunity by Heme Oxygenase-1
title_fullStr Modulation of Antiviral Immunity by Heme Oxygenase-1
title_full_unstemmed Modulation of Antiviral Immunity by Heme Oxygenase-1
title_sort Modulation of Antiviral Immunity by Heme Oxygenase-1
dc.creator.none.fl_str_mv Espinoza, Janyra A
González-Muñoz, Pablo Alberto
Kalergis, Alexis M
author Espinoza, Janyra A
author_facet Espinoza, Janyra A
González-Muñoz, Pablo Alberto
Kalergis, Alexis M
author_role author
author2 González-Muñoz, Pablo Alberto
Kalergis, Alexis M
author2_role author
author
description Heme oxygenase-1 (H0-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. In addition, recent studies have reported that HO-1 can exert a significant antiviral activity against a wide variety of viruses, including HIV, hepatitis C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue virus, and Ebola virus, among others. Herein, we address the current understanding of the functional significance of HO-1 against a variety of viruses and its potential as a therapeutic strategy to prevent and control viral infections. Furthermore, we review the most important features of the immunoregulatory functions for this enzyme. Keywords. KeyWords Plus:HEPATITIS-C VIRUS; DENDRITIC CELL MATURATION; INFLUENZA-VIRUS; MICROSATELLITE POLYMORPHISM; PROMOTER POLYMORPHISM; INTERFERON RESPONSE; HUMAN HEPATOCYTES; OXIDANT INJURY; HO-1 PROMOTER; REPLICATION
publishDate 2017
dc.date.issued.es_CL.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2018-10-01T19:30:04Z
2022-07-07T15:17:23Z
dc.date.available.none.fl_str_mv 2018-10-01T19:30:04Z
2022-07-07T15:17:23Z
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url https://hdl.handle.net/10533/220729
dc.language.iso.none.fl_str_mv eng
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dc.relation.doi.es_CL.fl_str_mv 10.1016/j.ajpath.2016.11.011
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dc.relation.uri.es_CL.fl_str_mv https://www.ncbi.nlm.nih.gov/pubmed/28082120
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spelling Kalergis, Alexis MGonzález-Muñoz, Pablo AlbertoEspinoza, Janyra A201710.1016/j.ajpath.2016.11.011https://hdl.handle.net/10533/220729http://purl.org/coar/access_right/c_abf2Modulation of Antiviral Immunity by Heme Oxygenase-1Espinoza, Janyra AGonzález-Muñoz, Pablo AlbertoKalergis, Alexis M2018-10-01T19:30:04Z2022-07-07T15:17:23Z2018-10-01T19:30:04Z2022-07-07T15:17:23Z2017Heme oxygenase-1 (H0-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. In addition, recent studies have reported that HO-1 can exert a significant antiviral activity against a wide variety of viruses, including HIV, hepatitis C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue virus, and Ebola virus, among others. Herein, we address the current understanding of the functional significance of HO-1 against a variety of viruses and its potential as a therapeutic strategy to prevent and control viral infections. Furthermore, we review the most important features of the immunoregulatory functions for this enzyme. Keywords. KeyWords Plus:HEPATITIS-C VIRUS; DENDRITIC CELL MATURATION; INFLUENZA-VIRUS; MICROSATELLITE POLYMORPHISM; PROMOTER POLYMORPHISM; INTERFERON RESPONSE; HUMAN HEPATOCYTES; OXIDANT INJURY; HO-1 PROMOTER; REPLICATION11400111140011virtual::24480-1WOS:000394558200002https://hdl.handle.net/10533/220729enginstname: Conicytreponame: Repositorio Digital RI2.010.1016/j.ajpath.2016.11.011info:eu-repo/grantAgreement//1140011info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477https://www.ncbi.nlm.nih.gov/pubmed/28082120info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 Chilehttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/Modulation of Antiviral Immunity by Heme Oxygenase-1American Journal Of PathologyArticuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttps://hdl.handle.net/10533/220729http://purl.org/coar/resource_type/c_2df8fbb1e855f4d7-6770-4af1-9b64-6bc395aaec3dvirtual::24480-1e855f4d7-6770-4af1-9b64-6bc395aaec3dvirtual::24480-1CC-LICENSElicense_rdfapplication/octet-stream1232https://repositorio.anid.cl/bitstreams/d72e4567-d49a-4eaf-8a14-53b6ead2c326/downloadf97bcfdf58f3e17b5cec231112dab5b1MD51LICENSElicense.txttext/plain1779https://repositorio.anid.cl/bitstreams/97e0feec-6c87-4af6-9fba-4ff01a8e1553/download593a6e7305c66c56041a9f9e15a649c1MD5210533/220729oai:repositorio.anid.cl:10533/2207292023-07-24 20:09:50.338http://creativecommons.org/licenses/by-nc-nd/3.0/cl/info:eu-repo/semantics/openAccesshttps://repositorio.anid.clRepositorio ANIDaletelier@anid.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