Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

Accumulation of extracellular amyloid beta peptide (Abeta), generated from amyloid precursor protein (APP) processing by beta- and gamma-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Abeta from APP

Bibliographic Details
Authors: Lee, J., Retamal, C., Cuitiño, L., Caruano-Yzermans, A., Shin, J. E., van Kerkhof, P., Marzolo, M. P., Bu, G.
Format: article
Status:Published version
Publication Date:2008
Country:Chile
Language:English
OAI Identifier:oai:repositorio.anid.cl:10533/240797
Online Access:https://hdl.handle.net/10533/240797
Access Level:Open access
Description
Summary:Accumulation of extracellular amyloid beta peptide (Abeta), generated from amyloid precursor protein (APP) processing by beta- and gamma-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Abeta from APP