Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes

Research following introduction of the MDCK model system to study epithelial polarity (1978) led to an initial paradigm that posited independent roles of the trans Golgi network (TGN) and recycling endosomes (RE) in the generation of, respectively, biosynthetic and recycling routes of plasma membran...

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Autores: Gonzalez, A., Rodriguez-Boulan E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/237148
Acceso en línea:https://hdl.handle.net/10533/237148
Access Level:acceso abierto
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spelling Rodriguez-Boulan E.Gonzalez, A.200910.1016/j.febslet.2009.10.050https://hdl.handle.net/10533/237148http://purl.org/coar/access_right/c_abf2Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routesGonzalez, A.Rodriguez-Boulan E.2019-12-18T18:14:52Z2022-07-07T22:05:09Z2019-12-18T18:14:52Z2022-07-07T22:05:09Z2009Research following introduction of the MDCK model system to study epithelial polarity (1978) led to an initial paradigm that posited independent roles of the trans Golgi network (TGN) and recycling endosomes (RE) in the generation of, respectively, biosynthetic and recycling routes of plasma membrane (PM) proteins to apical and basolateral PM domains. This model dominated the field for 20 years. However, studies over the past decade and the discovery of the involvement of clathrin and clathrin adaptors in protein trafficking to the basolateral PM has led to a new paradigm. TGN and RE are now believed to cooperate closely in both biosynthetic and recycling trafficking routes. Here, we critically review these recent advances and the questions that remain unanswered.FONDAPFONDAP1398000113980001virtual::27119-1WOS:000272421200009https://hdl.handle.net/10533/237148enginstname: Conicytreponame: Repositorio Digital RI2.010.1016/j.febslet.2009.10.050info:eu-repo/grantAgreement/Fondap/13980001https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286365/Atribución-NoComercial-SinDerivadas 3.0 Chilehttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/info:eu-repo/semantics/openAccessClathrin and AP1B: Key roles in basolateral trafficking and transendosomal routesFebs Letters. Special Issue “The Golgi Complex”Articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttps://hdl.handle.net/10533/237148http://purl.org/coar/resource_type/c_2df8fbb14c0c28ba-308a-47c1-afb7-2607f38e4c08virtual::27119-14c0c28ba-308a-47c1-afb7-2607f38e4c08virtual::27119-110533/237148oai:repositorio.anid.cl:10533/2371482023-07-24 21:05:59.317https://repositorio.anid.clRepositorio ANIDaletelier@anid.cl
dc.title.none.fl_str_mv Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
dc.title.journal.none.fl_str_mv Febs Letters. Special Issue “The Golgi Complex”
title Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
spellingShingle Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
Gonzalez, A.
title_short Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
title_full Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
title_fullStr Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
title_full_unstemmed Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
title_sort Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes
dc.creator.none.fl_str_mv Gonzalez, A.
Rodriguez-Boulan E.
author Gonzalez, A.
author_facet Gonzalez, A.
Rodriguez-Boulan E.
author_role author
author2 Rodriguez-Boulan E.
author2_role author
description Research following introduction of the MDCK model system to study epithelial polarity (1978) led to an initial paradigm that posited independent roles of the trans Golgi network (TGN) and recycling endosomes (RE) in the generation of, respectively, biosynthetic and recycling routes of plasma membrane (PM) proteins to apical and basolateral PM domains. This model dominated the field for 20 years. However, studies over the past decade and the discovery of the involvement of clathrin and clathrin adaptors in protein trafficking to the basolateral PM has led to a new paradigm. TGN and RE are now believed to cooperate closely in both biosynthetic and recycling trafficking routes. Here, we critically review these recent advances and the questions that remain unanswered.
publishDate 2009
dc.date.issued.none.fl_str_mv 2009
dc.date.accessioned.none.fl_str_mv 2019-12-18T18:14:52Z
2022-07-07T22:05:09Z
dc.date.available.none.fl_str_mv 2019-12-18T18:14:52Z
2022-07-07T22:05:09Z
dc.type.none.fl_str_mv Articulo
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.openaire.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.folio.none.fl_str_mv 13980001
13980001
dc.identifier.idwos.none.fl_str_mv WOS:000272421200009
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10533/237148
identifier_str_mv 13980001
WOS:000272421200009
url https://hdl.handle.net/10533/237148
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv instname: Conicyt
reponame: Repositorio Digital RI2.0
dc.relation.doi.none.fl_str_mv 10.1016/j.febslet.2009.10.050
dc.relation.projectid.none.fl_str_mv info:eu-repo/grantAgreement/Fondap/13980001
dc.relation.uri.none.fl_str_mv https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286365/
dc.rights.none.fl_str_mv Atribución-NoComercial-SinDerivadas 3.0 Chile
http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rights.driver.none.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 3.0 Chile
http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
eu_rights_str_mv openAccess
repository.name.fl_str_mv Repositorio ANID
repository.mail.fl_str_mv aletelier@anid.cl
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