Determination of the stoichiometry between alpha- and gamma 1 subunits of the bk channel using lret

Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to more negative potentials. However

Detalhes bibliográficos
Autores: Carrasquel-Ursulaez, Willy, Alvarez, Osvaldo, Bezanilla, Francisco, Latorre, Ramón
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/231948
Acesso em linha:https://hdl.handle.net/10533/231948
Access Level:acceso abierto
Descrição
Resumo:Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to more negative potentials. However