POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)

Ryanodine receptors have a central role as the calcium release channels of the sarcoplasmic reticulum. In the heart, they allow the massive release of calcium that triggers heart muscle contraction. Ryanodine receptors are very sensitive to redox agents that produce reversible redox modifications, s...

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Detalles Bibliográficos
Autores: Donoso Laurent, Paulina, Hidalgo, Cecilia, Sanchez Vergara, Gina Luisa
Tipo de recurso: capítulo de libro
Estado:Versión publicada
Fecha de publicación:2014
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/164725
Acceso en línea:https://hdl.handle.net/10533/164725
Access Level:acceso abierto
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spelling Sanchez Vergara, Gina LuisaHidalgo, CeciliaDonoso Laurent, Paulina2014https://hdl.handle.net/10533/164725http://purl.org/coar/access_right/c_abf2POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)10461031ALEMANIADonoso Laurent, PaulinaHidalgo, CeciliaSanchez Vergara, Gina LuisaLaher, Ismail2016-12-27T21:47:45Z2022-06-17T21:16:15Z2016-12-27T21:47:45Z2022-06-17T21:16:15Z2014Ryanodine receptors have a central role as the calcium release channels of the sarcoplasmic reticulum. In the heart, they allow the massive release of calcium that triggers heart muscle contraction. Ryanodine receptors are very sensitive to redox agents that produce reversible redox modifications, such as S-nitrosylation and S-glutathionylation of hyper-reactive cysteine residues. In this chapter, we will discuss the effects of some of these modifications and the available evidence for their physiological role and the possible enzymatic sources responsible for these modifications.FONDECYT14178FONDECYT1110257978-3-642-30017-2978-3-642-30019-6978-3-642-30018-9https://hdl.handle.net/10533/164725engSPRINGER VERLAGinstname: Conicytreponame: Repositorio Digital RI2.0instname: Conicytreponame: Repositorio Digital RI 2.0info:eu-repo/grantAgreement/Fondecyt/1110257info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479http://www.springer.com/us/book/9783642300172info:eu-repo/semantics/openAccessPOSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)SYSTEMS BIOLOGY OF FREE RADICALS AND ANTIOXIDANTSCapitulo de libroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPartCapituloLibrohttps://hdl.handle.net/10533/164725FONDECYThttp://purl.org/coar/resource_type/c_3248f7c854fa-c0af-4560-b56c-7b6756ccc367virtual::12519-1f7c854fa-c0af-4560-b56c-7b6756ccc367virtual::12519-110533/164725oai:repositorio.anid.cl:10533/1647252023-07-04 01:13:16.653https://repositorio.anid.clRepositorio ANIDaletelier@anid.cl
dc.title.none.fl_str_mv POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
dc.title.libro.none.fl_str_mv SYSTEMS BIOLOGY OF FREE RADICALS AND ANTIOXIDANTS
title POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
spellingShingle POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
Donoso Laurent, Paulina
title_short POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
title_full POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
title_fullStr POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
title_full_unstemmed POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
title_sort POSTTRANSLATIONAL MODIFICATIONS OF CARDIAC RYANODINE RECEPTORS/CALCIUM RELEASE CHANNELS BY REACTIVE OXYGEN (ROS) AND REACTIVE NITROGEN SPECIES (RNS)
dc.creator.none.fl_str_mv Donoso Laurent, Paulina
Hidalgo, Cecilia
Sanchez Vergara, Gina Luisa
dc.creator.libro.none.fl_str_mv Laher, Ismail
author Donoso Laurent, Paulina
author_facet Donoso Laurent, Paulina
Hidalgo, Cecilia
Sanchez Vergara, Gina Luisa
author_role author
author2 Hidalgo, Cecilia
Sanchez Vergara, Gina Luisa
author2_role author
author
description Ryanodine receptors have a central role as the calcium release channels of the sarcoplasmic reticulum. In the heart, they allow the massive release of calcium that triggers heart muscle contraction. Ryanodine receptors are very sensitive to redox agents that produce reversible redox modifications, such as S-nitrosylation and S-glutathionylation of hyper-reactive cysteine residues. In this chapter, we will discuss the effects of some of these modifications and the available evidence for their physiological role and the possible enzymatic sources responsible for these modifications.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014
dc.date.accessioned.none.fl_str_mv 2016-12-27T21:47:45Z
2022-06-17T21:16:15Z
dc.date.available.none.fl_str_mv 2016-12-27T21:47:45Z
2022-06-17T21:16:15Z
dc.type.none.fl_str_mv Capitulo de libro
info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.folio.none.fl_str_mv 1110257
dc.identifier.isbn.none.fl_str_mv 978-3-642-30017-2
978-3-642-30019-6
978-3-642-30018-9
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10533/164725
identifier_str_mv 1110257
978-3-642-30017-2
978-3-642-30019-6
978-3-642-30018-9
url https://hdl.handle.net/10533/164725
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv instname: Conicyt
reponame: Repositorio Digital RI2.0
instname: Conicyt
reponame: Repositorio Digital RI 2.0
dc.relation.projectid.none.fl_str_mv info:eu-repo/grantAgreement/Fondecyt/1110257
dc.relation.set.none.fl_str_mv info:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.relation.uri.none.fl_str_mv http://www.springer.com/us/book/9783642300172
dc.rights.driver.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.editorial.none.fl_str_mv SPRINGER VERLAG
repository.name.fl_str_mv Repositorio ANID
repository.mail.fl_str_mv aletelier@anid.cl
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score 15,811543

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