Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus
Glyphosate (GLY) is the most used herbicide worldwide and its effects on anurans are well known. Pollutants can cause physiological and morphological effects. Therefore, this study evaluated the effects of GLY on hepatic melanomacrophages as a response to environmental stressors. Three treatments we...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/172514 |
| Acceso en línea: | http://dx.doi.org/10.1007/s11356-016-6153-z http://hdl.handle.net/11449/172514 |
| Access Level: | acceso abierto |
| Palabra clave: | Genotoxic effects Glyphosate Hemosiderin Melanin Melanomacrophages Morphological responses |
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Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasusGenotoxic effectsGlyphosateHemosiderinMelaninMelanomacrophagesMorphological responsesGlyphosate (GLY) is the most used herbicide worldwide and its effects on anurans are well known. Pollutants can cause physiological and morphological effects. Therefore, this study evaluated the effects of GLY on hepatic melanomacrophages as a response to environmental stressors. Three treatments were exposed to different concentrations of pure GLY (100, 1000, and 10,000 μg g−1, respectively), and there was also a control group. After the experimental time, liver and blood were analyzed. Melanomacrophages (MMCs) were located between the hepatocyte cordons, close to sinusoids. GLY increased the melanin area in MMCs of Leptodactylus latinasus exposed since lowest concentration until highest concentration. GLY also changed the occurrence of hepatic catabolism pigments into melanomacrophages and erythrocyte nuclear abnormalities; therefore, it can interfere with the hepatic metabolism. In conclusion, GLY promotes alterations in the hepatic tissue and erythrocyte nuclear abnormalities. Furthermore, MMCs may be useful as morphological responses of GLY effects.PROICO 9401 Área Zoología Facultad de Química Bioquímica y Farmacia Universidad Nacional de San Luis, Chacabuco 917Department of Biology São Paulo State University (UNESP) IBILCE, Rua Cristóvão Colombo, 2265, Jardim NazarethCentro de Investigaciones del Medio Ambiente Departamento de Química Facultad de Ciencias Exactas Universidad Nacional de La Plata CONICETDepartment of Biology São Paulo State University (UNESP) IBILCE, Rua Cristóvão Colombo, 2265, Jardim NazarethUniversidad Nacional de San LuisUniversidade Estadual Paulista (Unesp)CONICET2018-12-11T17:00:45Z2018-12-11T17:00:45Z2016-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9852-9861application/pdfhttp://dx.doi.org/10.1007/s11356-016-6153-zEnvironmental Science and Pollution Research, v. 23, n. 10, p. 9852-9861, 2016.1614-74990944-1344http://hdl.handle.net/11449/17251410.1007/s11356-016-6153-z2-s2.0-849577167642-s2.0-84957716764.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Research0,858info:eu-repo/semantics/openAccessPérez-Iglesias, Juan ManuelFranco-Belussi, Lilian [UNESP]Moreno, LilianaTripole, Susanade Oliveira, Classius [UNESP]Natale, Guillermo Sebastián2024-10-25T13:50:12Zoai:repositorio.unesp.br:11449/172514Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-10-25T13:50:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| title |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| spellingShingle |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus Pérez-Iglesias, Juan Manuel Genotoxic effects Glyphosate Hemosiderin Melanin Melanomacrophages Morphological responses |
| title_short |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| title_full |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| title_fullStr |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| title_full_unstemmed |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| title_sort |
Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus |
| dc.creator.none.fl_str_mv |
Pérez-Iglesias, Juan Manuel Franco-Belussi, Lilian [UNESP] Moreno, Liliana Tripole, Susana de Oliveira, Classius [UNESP] Natale, Guillermo Sebastián |
| author |
Pérez-Iglesias, Juan Manuel |
| author_facet |
Pérez-Iglesias, Juan Manuel Franco-Belussi, Lilian [UNESP] Moreno, Liliana Tripole, Susana de Oliveira, Classius [UNESP] Natale, Guillermo Sebastián |
| author_role |
author |
| author2 |
Franco-Belussi, Lilian [UNESP] Moreno, Liliana Tripole, Susana de Oliveira, Classius [UNESP] Natale, Guillermo Sebastián |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Nacional de San Luis Universidade Estadual Paulista (Unesp) CONICET |
| dc.subject.por.fl_str_mv |
Genotoxic effects Glyphosate Hemosiderin Melanin Melanomacrophages Morphological responses |
| topic |
Genotoxic effects Glyphosate Hemosiderin Melanin Melanomacrophages Morphological responses |
| description |
Glyphosate (GLY) is the most used herbicide worldwide and its effects on anurans are well known. Pollutants can cause physiological and morphological effects. Therefore, this study evaluated the effects of GLY on hepatic melanomacrophages as a response to environmental stressors. Three treatments were exposed to different concentrations of pure GLY (100, 1000, and 10,000 μg g−1, respectively), and there was also a control group. After the experimental time, liver and blood were analyzed. Melanomacrophages (MMCs) were located between the hepatocyte cordons, close to sinusoids. GLY increased the melanin area in MMCs of Leptodactylus latinasus exposed since lowest concentration until highest concentration. GLY also changed the occurrence of hepatic catabolism pigments into melanomacrophages and erythrocyte nuclear abnormalities; therefore, it can interfere with the hepatic metabolism. In conclusion, GLY promotes alterations in the hepatic tissue and erythrocyte nuclear abnormalities. Furthermore, MMCs may be useful as morphological responses of GLY effects. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-05-01 2018-12-11T17:00:45Z 2018-12-11T17:00:45Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11356-016-6153-z Environmental Science and Pollution Research, v. 23, n. 10, p. 9852-9861, 2016. 1614-7499 0944-1344 http://hdl.handle.net/11449/172514 10.1007/s11356-016-6153-z 2-s2.0-84957716764 2-s2.0-84957716764.pdf |
| url |
http://dx.doi.org/10.1007/s11356-016-6153-z http://hdl.handle.net/11449/172514 |
| identifier_str_mv |
Environmental Science and Pollution Research, v. 23, n. 10, p. 9852-9861, 2016. 1614-7499 0944-1344 10.1007/s11356-016-6153-z 2-s2.0-84957716764 2-s2.0-84957716764.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Environmental Science and Pollution Research 0,858 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
9852-9861 application/pdf |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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1853671498504470528 |
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15.301603 |