Leukotriene B4 licenses inflammasome activation to enhance skin host defense

Bethany Moore (University of Michigan, Ann Arbor, MI) for providing the MRSA USA300 LAC strain and Roger Plaut (Food and Drug Administration, Silver Spring, MD) for providing the bioluminescent USA300 (NRS384 lux) MRSA strain. This paper was supported by NIH Grants R01HL124159-01 and RAI149207A (to...

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Autores: Salina, Ana Carolina Guerta, Brandt, Stephanie L., Klopfenstein, Nathan, Blackman, Amondrea, Bazzano, Júlia Miranda Ribeiro, Nunes, Anderson Sá, Glosson, Nicole Byers, Brodskyng, Claudia Ida, Tavares, Natalia Machado, Silva, Icaro Bonyek Santos da, Medeiros, Alexandra I., Serezani, C. Henrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/45771
Acceso en línea:https://arca.fiocruz.br/handle/icict/45771
Access Level:acceso abierto
Palabra clave:Inflamassoma
Leucotrieno
Pele
Imunidade
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oai_identifier_str oai:arca.fiocruz.br:icict/45771
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Leukotriene B4 licenses inflammasome activation to enhance skin host defense
title Leukotriene B4 licenses inflammasome activation to enhance skin host defense
spellingShingle Leukotriene B4 licenses inflammasome activation to enhance skin host defense
Salina, Ana Carolina Guerta
Inflamassoma
Leucotrieno
Pele
Imunidade
title_short Leukotriene B4 licenses inflammasome activation to enhance skin host defense
title_full Leukotriene B4 licenses inflammasome activation to enhance skin host defense
title_fullStr Leukotriene B4 licenses inflammasome activation to enhance skin host defense
title_full_unstemmed Leukotriene B4 licenses inflammasome activation to enhance skin host defense
title_sort Leukotriene B4 licenses inflammasome activation to enhance skin host defense
dc.creator.none.fl_str_mv Salina, Ana Carolina Guerta
Brandt, Stephanie L.
Klopfenstein, Nathan
Blackman, Amondrea
Bazzano, Júlia Miranda Ribeiro
Nunes, Anderson Sá
Glosson, Nicole Byers
Brodskyng, Claudia Ida
Tavares, Natalia Machado
Silva, Icaro Bonyek Santos da
Medeiros, Alexandra I.
Serezani, C. Henrique
author Salina, Ana Carolina Guerta
author_facet Salina, Ana Carolina Guerta
Brandt, Stephanie L.
Klopfenstein, Nathan
Blackman, Amondrea
Bazzano, Júlia Miranda Ribeiro
Nunes, Anderson Sá
Glosson, Nicole Byers
Brodskyng, Claudia Ida
Tavares, Natalia Machado
Silva, Icaro Bonyek Santos da
Medeiros, Alexandra I.
Serezani, C. Henrique
author_role author
author2 Brandt, Stephanie L.
Klopfenstein, Nathan
Blackman, Amondrea
Bazzano, Júlia Miranda Ribeiro
Nunes, Anderson Sá
Glosson, Nicole Byers
Brodskyng, Claudia Ida
Tavares, Natalia Machado
Silva, Icaro Bonyek Santos da
Medeiros, Alexandra I.
Serezani, C. Henrique
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv Inflamassoma
Leucotrieno
Pele
Imunidade
topic Inflamassoma
Leucotrieno
Pele
Imunidade
description Bethany Moore (University of Michigan, Ann Arbor, MI) for providing the MRSA USA300 LAC strain and Roger Plaut (Food and Drug Administration, Silver Spring, MD) for providing the bioluminescent USA300 (NRS384 lux) MRSA strain. This paper was supported by NIH Grants R01HL124159-01 and RAI149207A (to C.H.S.), T32AI060519 (to S.L.B.), and T32AI138932 (to N.K.); FAPESP Grants 2018/01622-9, 2017/04786-0 (to A.C.G.S.), 2017/19870-6 (to A.I.M.), and 2019/10839-4 (to A.S.-N.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-21T18:15:32Z
dc.date.available.fl_str_mv 2021-01-21T18:15:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALINA, Ana Carolina Guerta et al. B4 licenses inflammasome activation to enhance skin host defense. Proceedings of the National Academy of Sciences, v. 117, n. 48, p. 30619–30627, 2020.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/45771
dc.identifier.issn.none.fl_str_mv 0027-8424
dc.identifier.doi.none.fl_str_mv 10.1073/pnas.2002732117
identifier_str_mv SALINA, Ana Carolina Guerta et al. B4 licenses inflammasome activation to enhance skin host defense. Proceedings of the National Academy of Sciences, v. 117, n. 48, p. 30619–30627, 2020.
0027-8424
10.1073/pnas.2002732117
url https://arca.fiocruz.br/handle/icict/45771
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2021-01-21T18:15:32Z2021-01-21T18:15:32Z2020SALINA, Ana Carolina Guerta et al. B4 licenses inflammasome activation to enhance skin host defense. Proceedings of the National Academy of Sciences, v. 117, n. 48, p. 30619–30627, 2020.0027-8424https://arca.fiocruz.br/handle/icict/4577110.1073/pnas.2002732117Bethany Moore (University of Michigan, Ann Arbor, MI) for providing the MRSA USA300 LAC strain and Roger Plaut (Food and Drug Administration, Silver Spring, MD) for providing the bioluminescent USA300 (NRS384 lux) MRSA strain. This paper was supported by NIH Grants R01HL124159-01 and RAI149207A (to C.H.S.), T32AI060519 (to S.L.B.), and T32AI138932 (to N.K.); FAPESP Grants 2018/01622-9, 2017/04786-0 (to A.C.G.S.), 2017/19870-6 (to A.I.M.), and 2019/10839-4 (to A.S.-N.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN / São Paulo State University. School of Pharmaceutical Sciences. Department of Biological Sciences. Araraquara, SP, Brazil / University of São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN / Indiana University School of Medicine. Department of Microbiology and Immunology,Indianapolis. IN.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN / Vanderbilt University Medical Center. Vanderbilt Institute of Infection, Immunology and Inflammation. Nashville, TN.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN / University of São Paulo. Institute of Biomedical Sciences. Department of Immunology. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.São Paulo State University. School of Pharmaceutical Sciences. Department of Biological Sciences. Araraquara, SP, Brazil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN / Vanderbilt University Medical Center. Microbiology, and Immunology. Department of Pathology. Nashville, TN / Vanderbilt University Medical Center. Vanderbilt Institute of Infection, Immunology and Inflammation. Nashville, TN / Vanderbilt University Medical Center. Center for Immunobiology. Nashville, TN.The initial production of inflammatory mediators dictates host defense as well as tissue injury. Inflammasome activation is a constituent of the inflammatory response by recognizing pathogen and host-derived products and eliciting the production of IL-1β and IL-18 in addition to inducing a type of inflammatory cell death termed "pyroptosis." Leukotriene B4 (LTB4) is a lipid mediator produced quickly (seconds to minutes) by phagocytes and induces chemotaxis, increases cytokine/chemokine production, and enhances antimicrobial effector functions. Whether LTB4 directly activates the inflammasome remains to be determined. Our data show that endogenously produced LTB4 is required for the expression of pro-IL-1β and enhances inflammasome assembly in vivo and in vitro. Furthermore, LTB4-mediated Bruton's tyrosine kinase (BTK) activation is required for inflammasome assembly in vivo as well for IL-1β–enhanced skin host defense. Together, these data unveil a new role for LTB4 in enhancing the expression and assembly of inflammasome components and suggest that while blocking LTB4 actions could be a promising therapeutic strategy to prevent inflammasome-mediated diseases, exogenous LTB4 can be used as an adjuvant to boost inflammasome-dependent host defense.engNational Academy of SciencesInflamassomaLeucotrienoPeleImunidadeLeukotriene B4 licenses inflammasome activation to enhance skin host defenseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSalina, Ana Carolina GuertaBrandt, Stephanie L.Klopfenstein, NathanBlackman, AmondreaBazzano, Júlia Miranda RibeiroNunes, Anderson SáGlosson, Nicole ByersBrodskyng, Claudia IdaTavares, Natalia MachadoSilva, Icaro Bonyek Santos daMedeiros, Alexandra I.Serezani, C. 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