Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice

Understanding the metabolism of toxigenic fungi in food is crucial for public health. Fungi of the Aspergillus section Flavi are widespread in tropical and subtropical regions, infecting and producing mycotoxins in peanuts, nuts, cereals, and fruits. Classical Molecular Networking on the Global Natu...

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Detalles Bibliográficos
Autores: Santos, Augusto Leonardo dos, Ferreira, Marcelo José Pena, Sartorelli, Patricia, Silva, Josué José da, Iamanaka, Beatriz Thie, Frisvad, Jens Christian, Taniwaki, Marta Hiromi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:Brasil
Institución:Instituto de Tecnologia de Alimentos (ITAL)
Repositorio:Repositório do Instituto de Tecnologia de Alimentos
Idioma:inglés
OAI Identifier:oai:http://repositorio.ital.sp.gov.br:123456789/866
Acceso en línea:http://repositorio.ital.sp.gov.br/jspui/handle/123456789/866
Access Level:acceso abierto
Palabra clave:PUFA
Oxylipin
Kojic acid
Dereplication
Aspergillus section Flavi
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spelling Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juicePUFAOxylipinKojic acidDereplicationAspergillus section FlaviUnderstanding the metabolism of toxigenic fungi in food is crucial for public health. Fungi of the Aspergillus section Flavi are widespread in tropical and subtropical regions, infecting and producing mycotoxins in peanuts, nuts, cereals, and fruits. Classical Molecular Networking on the Global Natural Products Social Molecular Networking (GNPS) platform was applied to organize and guide the analysis of polyunsaturated fatty acids (PUFAs) and oxylipins, which are strongly associated with chemical communication between fungi and host plants during infection. Dereplication and molecular networking enabled visualization of the metabolome of A. novoparasiticus (ITAL-Y174 strain) incubated in sugarcane juice to mimic the fungal chemical response to plant lipids. The ITAL-Y174 strain produced PUFAs that differed from those of sugarcane. Oxylipins were detected early in the incubation (PGE1, 9,10-DiHOME, 13S-HODE). No known mycotoxins for A. novoparasiticus were detected, and kojic acid was identified, indicating a novel pathway to produce this important industrial natural product.FAPESP, CNPqFood Chemistry2025-08-20T10:42:31Z2025-08-20T10:42:31Z2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://repositorio.ital.sp.gov.br/jspui/handle/123456789/866© 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.info:eu-repo/semantics/openAccessengreponame:Repositório do Instituto de Tecnologia de Alimentosinstname:Instituto de Tecnologia de Alimentos (ITAL)instacron:ITALSantos, Augusto Leonardo dosFerreira, Marcelo José PenaSartorelli, PatriciaSilva, Josué José daIamanaka, Beatriz ThieFrisvad, Jens ChristianTaniwaki, Marta Hiromi2025-10-02T17:25:02Zoai:http://repositorio.ital.sp.gov.br:123456789/866Repositório InstitucionalPUBhttp://repositorio.ital.sp.gov.br/oai/requestbjftsec@ital.sp.gov.br || bjftsec@ital.sp.gov.bropendoar:2025-10-02T17:25:02Repositório do Instituto de Tecnologia de Alimentos - Instituto de Tecnologia de Alimentos (ITAL)false
dc.title.none.fl_str_mv Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
title Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
spellingShingle Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
Santos, Augusto Leonardo dos
PUFA
Oxylipin
Kojic acid
Dereplication
Aspergillus section Flavi
title_short Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
title_full Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
title_fullStr Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
title_full_unstemmed Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
title_sort Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
dc.creator.none.fl_str_mv Santos, Augusto Leonardo dos
Ferreira, Marcelo José Pena
Sartorelli, Patricia
Silva, Josué José da
Iamanaka, Beatriz Thie
Frisvad, Jens Christian
Taniwaki, Marta Hiromi
author Santos, Augusto Leonardo dos
author_facet Santos, Augusto Leonardo dos
Ferreira, Marcelo José Pena
Sartorelli, Patricia
Silva, Josué José da
Iamanaka, Beatriz Thie
Frisvad, Jens Christian
Taniwaki, Marta Hiromi
author_role author
author2 Ferreira, Marcelo José Pena
Sartorelli, Patricia
Silva, Josué José da
Iamanaka, Beatriz Thie
Frisvad, Jens Christian
Taniwaki, Marta Hiromi
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv PUFA
Oxylipin
Kojic acid
Dereplication
Aspergillus section Flavi
topic PUFA
Oxylipin
Kojic acid
Dereplication
Aspergillus section Flavi
description Understanding the metabolism of toxigenic fungi in food is crucial for public health. Fungi of the Aspergillus section Flavi are widespread in tropical and subtropical regions, infecting and producing mycotoxins in peanuts, nuts, cereals, and fruits. Classical Molecular Networking on the Global Natural Products Social Molecular Networking (GNPS) platform was applied to organize and guide the analysis of polyunsaturated fatty acids (PUFAs) and oxylipins, which are strongly associated with chemical communication between fungi and host plants during infection. Dereplication and molecular networking enabled visualization of the metabolome of A. novoparasiticus (ITAL-Y174 strain) incubated in sugarcane juice to mimic the fungal chemical response to plant lipids. The ITAL-Y174 strain produced PUFAs that differed from those of sugarcane. Oxylipins were detected early in the incubation (PGE1, 9,10-DiHOME, 13S-HODE). No known mycotoxins for A. novoparasiticus were detected, and kojic acid was identified, indicating a novel pathway to produce this important industrial natural product.
publishDate 2025
dc.date.none.fl_str_mv 2025-08-20T10:42:31Z
2025-08-20T10:42:31Z
2025
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ital.sp.gov.br/jspui/handle/123456789/866
url http://repositorio.ital.sp.gov.br/jspui/handle/123456789/866
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Food Chemistry
publisher.none.fl_str_mv Food Chemistry
dc.source.none.fl_str_mv reponame:Repositório do Instituto de Tecnologia de Alimentos
instname:Instituto de Tecnologia de Alimentos (ITAL)
instacron:ITAL
instname_str Instituto de Tecnologia de Alimentos (ITAL)
instacron_str ITAL
institution ITAL
reponame_str Repositório do Instituto de Tecnologia de Alimentos
collection Repositório do Instituto de Tecnologia de Alimentos
repository.name.fl_str_mv Repositório do Instituto de Tecnologia de Alimentos - Instituto de Tecnologia de Alimentos (ITAL)
repository.mail.fl_str_mv bjftsec@ital.sp.gov.br || bjftsec@ital.sp.gov.br
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