Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes

A series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NM...

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Authors: Maru, Minaxi S., Shah, Manish K.
Format: article
Status:Published version
Publication Date:2015
Country:Brasil
Institution:Universidade Federal de Mato Grosso do Sul (UFMS)
Repository:Orbital - The Electronic Journal of Chemistry (Campo Grande)
Language:English
OAI Identifier:oai:periodicos.ufms.br:article/17878
Online Access:https://periodicos.ufms.br/index.php/orbital/article/view/17878
Access Level:Open access
Keyword:Co(II) complexes
1H-benzo[d]imidazoles
antimicrobial activity
antimycobacterial activity
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oai_identifier_str oai:periodicos.ufms.br:article/17878
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spelling Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) ComplexesCo(II) complexes1H-benzo[d]imidazolesantimicrobial activityantimycobacterial activityA series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NMR and UV-Visible spectroscopy, Thermogravimetric analysis, Magnetic susceptibility, Molar conductance and Elemental analysis. The 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g have been synthesized by cyclocondensation of benzene-1,2-diamine with 2-chloroquinoline-3-carbaldehydes by using ceric ammonium nitrate as a catalyst in presence of hydrogen peroxide as an oxidant. The structures of all ligands were confirmed by IR, Mass, UV-Visible, 1H NMR and 13C NMR spectroscopy. All ligands 3a-g and their Co(II) complexes 3¢a-g were screened for their in vitro antimicrobial activity using twofold serial dilution technique against standard MTCC strains of two Gram-positive Staphylococcus aureus and Streptococcus pyogenes, two Gram-negative Escherichia coli and Pseudomonas aeruginosa bacteria and three Candida albicans, Aspergillus niger and Aspergillus clavatus fungus in comparison with standard drugs. All ligands 3a-g and complexes 3¢a-g also evaluated for antimycobacterial activity against standard Mycobacterium tuberculosis H37Rv strain. DOI: http://dx.doi.org/10.17807/orbital.v7i2.530Instituto de Química, Universidade Federal de Mato Grosso do Sul2015-06-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfapplication/x-rarhttps://periodicos.ufms.br/index.php/orbital/article/view/17878Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 2 - April-June 2015; 108-121Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 2 - April-June 2015; 108-1211984-6428reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande)instname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSenghttps://periodicos.ufms.br/index.php/orbital/article/view/17878/12270https://periodicos.ufms.br/index.php/orbital/article/view/17878/12271Copyright (c) 2015 Orbital: The Electronic Journal of Chemistryhttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMaru, Minaxi S.Shah, Manish K.2023-01-20T11:04:58Zoai:periodicos.ufms.br:article/17878Revistahttps://periodicos.ufms.br/index.php/orbital/indexPUBhttps://periodicos.ufms.br/index.php/orbital/oaieditor.orbital@ufms.br || marcos.amaral@ufms.br1984-64281984-6428opendoar:2023-01-20T11:04:58Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.none.fl_str_mv Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
title Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
spellingShingle Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
Maru, Minaxi S.
Co(II) complexes
1H-benzo[d]imidazoles
antimicrobial activity
antimycobacterial activity
title_short Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
title_full Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
title_fullStr Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
title_full_unstemmed Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
title_sort Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
dc.creator.none.fl_str_mv Maru, Minaxi S.
Shah, Manish K.
author Maru, Minaxi S.
author_facet Maru, Minaxi S.
Shah, Manish K.
author_role author
author2 Shah, Manish K.
author2_role author
dc.subject.por.fl_str_mv Co(II) complexes
1H-benzo[d]imidazoles
antimicrobial activity
antimycobacterial activity
topic Co(II) complexes
1H-benzo[d]imidazoles
antimicrobial activity
antimycobacterial activity
description A series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NMR and UV-Visible spectroscopy, Thermogravimetric analysis, Magnetic susceptibility, Molar conductance and Elemental analysis. The 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g have been synthesized by cyclocondensation of benzene-1,2-diamine with 2-chloroquinoline-3-carbaldehydes by using ceric ammonium nitrate as a catalyst in presence of hydrogen peroxide as an oxidant. The structures of all ligands were confirmed by IR, Mass, UV-Visible, 1H NMR and 13C NMR spectroscopy. All ligands 3a-g and their Co(II) complexes 3¢a-g were screened for their in vitro antimicrobial activity using twofold serial dilution technique against standard MTCC strains of two Gram-positive Staphylococcus aureus and Streptococcus pyogenes, two Gram-negative Escherichia coli and Pseudomonas aeruginosa bacteria and three Candida albicans, Aspergillus niger and Aspergillus clavatus fungus in comparison with standard drugs. All ligands 3a-g and complexes 3¢a-g also evaluated for antimycobacterial activity against standard Mycobacterium tuberculosis H37Rv strain. DOI: http://dx.doi.org/10.17807/orbital.v7i2.530
publishDate 2015
dc.date.none.fl_str_mv 2015-06-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufms.br/index.php/orbital/article/view/17878
url https://periodicos.ufms.br/index.php/orbital/article/view/17878
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.ufms.br/index.php/orbital/article/view/17878/12270
https://periodicos.ufms.br/index.php/orbital/article/view/17878/12271
dc.rights.driver.fl_str_mv Copyright (c) 2015 Orbital: The Electronic Journal of Chemistry
https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Orbital: The Electronic Journal of Chemistry
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/x-rar
dc.publisher.none.fl_str_mv Instituto de Química, Universidade Federal de Mato Grosso do Sul
publisher.none.fl_str_mv Instituto de Química, Universidade Federal de Mato Grosso do Sul
dc.source.none.fl_str_mv Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 2 - April-June 2015; 108-121
Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 2 - April-June 2015; 108-121
1984-6428
reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande)
instname:Universidade Federal de Mato Grosso do Sul (UFMS)
instacron:UFMS
instname_str Universidade Federal de Mato Grosso do Sul (UFMS)
instacron_str UFMS
institution UFMS
reponame_str Orbital - The Electronic Journal of Chemistry (Campo Grande)
collection Orbital - The Electronic Journal of Chemistry (Campo Grande)
repository.name.fl_str_mv Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS)
repository.mail.fl_str_mv editor.orbital@ufms.br || marcos.amaral@ufms.br
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score 15,301603

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