Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines:...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2013 |
| País: | Brasil |
| Recursos: | Universidade Federal do Ceará (UFC) |
| Repositório: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.ufc.br:riufc/7208 |
| Acesso em linha: | http://www.repositorio.ufc.br/handle/riufc/7208 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Paládio Neoplasias |
| Resumo: | A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth. |
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