Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.

Detalhes bibliográficos
Autores: Silva Junior, Rodrigo Pacheco, Peruchetti, Diogo Barros, Rocco, Patricia Tieken Macedo, Schmaier, Alvin H., Silva, Patrícia Machado Rodrigues e, Martins, Marco Aurélio, Carvalho, Vinícius Frias, Pinheiro, Ana Acácia Sá, Neves, Celso Caruso
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/45485
Acesso em linha:https://arca.fiocruz.br/handle/icict/45485
Access Level:acceso abierto
Palavra-chave:COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Sistema renina-angiotensina
Renin-angiotensin system
id BR_f8bfbfddbb94cd8bc0d6d2b7af55a203
oai_identifier_str oai:arca.fiocruz.br:icict/45485
network_acronym_str BR
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dc.title.none.fl_str_mv Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
title Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
spellingShingle Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
Silva Junior, Rodrigo Pacheco
COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Sistema renina-angiotensina
COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Renin-angiotensin system
title_short Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
title_full Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
title_fullStr Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
title_full_unstemmed Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
title_sort Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
dc.creator.none.fl_str_mv Silva Junior, Rodrigo Pacheco
Peruchetti, Diogo Barros
Rocco, Patricia Tieken Macedo
Schmaier, Alvin H.
Silva, Patrícia Machado Rodrigues e
Martins, Marco Aurélio
Carvalho, Vinícius Frias
Pinheiro, Ana Acácia Sá
Neves, Celso Caruso
author Silva Junior, Rodrigo Pacheco
author_facet Silva Junior, Rodrigo Pacheco
Peruchetti, Diogo Barros
Rocco, Patricia Tieken Macedo
Schmaier, Alvin H.
Silva, Patrícia Machado Rodrigues e
Martins, Marco Aurélio
Carvalho, Vinícius Frias
Pinheiro, Ana Acácia Sá
Neves, Celso Caruso
author_role author
author2 Peruchetti, Diogo Barros
Rocco, Patricia Tieken Macedo
Schmaier, Alvin H.
Silva, Patrícia Machado Rodrigues e
Martins, Marco Aurélio
Carvalho, Vinícius Frias
Pinheiro, Ana Acácia Sá
Neves, Celso Caruso
author2_role author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Sistema renina-angiotensina
topic COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Sistema renina-angiotensina
COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Renin-angiotensin system
dc.subject.en.none.fl_str_mv COVID-19
SARS-CoV-2
Angiotensin II
Hypertension
Renin-angiotensin system
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-01T19:55:32Z
dc.date.available.fl_str_mv 2021-01-01T19:55:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/45485
dc.identifier.issn.none.fl_str_mv 1040-0605
dc.identifier.doi.none.fl_str_mv 10.1152/ajplung.00286.2020
identifier_str_mv AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020.
1040-0605
10.1152/ajplung.00286.2020
url https://arca.fiocruz.br/handle/icict/45485
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2021-01-01T19:55:32Z2021-01-01T19:55:32Z2020AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020.1040-0605https://arca.fiocruz.br/handle/icict/4548510.1152/ajplung.00286.2020engAmerican Physiological SocietyCOVID-19SARS-CoV-2Angiotensin IIHypertensionSistema renina-angiotensinaCOVID-19SARS-CoV-2Angiotensin IIHypertensionRenin-angiotensin systemRole of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Medicina Reginerativa. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.Case Western Reserve University. Cleveland, Ohio, USA / University Hospitals Cleveland Medical Center. Cleveland, Ohio, USA.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Medicina Reginerativa. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.A new form of severe acute respiratory syndrome (SARS) caused by SARS-coronavirus 2 (CoV-2), called COVID-19, has become a global threat in 2020. The mortality rate from COVID-19 is high in hypertensive patients, making this association especially dangerous. There appears to be a consensus, despite the lack of experimental data, that angiotensin II (ANG II) is linked to the pathogenesis of COVID-19. This process may occur due to acquired deficiency of angiotensin-converting enzyme 2 (ACE2), resulting in reduced degradation of ANG II. Furthermore, ANG II has a critical role in the genesis and worsening of hypertension. In this context, the idea that there is a surge in the level of ANG II with COVID-19 infection, causing multiple organ injuries in hypertensive patients becomes attractive. However, the role of other components of the renin angiotensin system (RAS) in this scenario requires elucidation. The identification of other RAS components in COVID-19 hypertension may provide both diagnostic and therapeutic benefits. Here, we summarize the pathophysiologic contributions of different components of RAS in hypertension and their possible correlation with poor outcome observed in hypertensive patients with COVID-19.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSilva Junior, Rodrigo PachecoPeruchetti, Diogo BarrosRocco, Patricia Tieken MacedoSchmaier, Alvin H.Silva, Patrícia Machado Rodrigues eMartins, Marco AurélioCarvalho, Vinícius FriasPinheiro, Ana Acácia SáNeves, Celso CarusoLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/c69589a7-cdee-4670-9579-722931c0f53e/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdfVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdfapplication/pdf303154https://arca.fiocruz.br/bitstreams/2388f981-3b2a-4f6e-889d-b3b64d31677d/downloaddcfc282d164f6b38f04c25da94f02104MD52trueAnonymousREADTEXTVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.txtVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.txtExtracted texttext/plain55853https://arca.fiocruz.br/bitstreams/efa047c9-cb4d-4efb-ba6a-4038d8b0f76a/download852d3c984989895130cfa1292ce66eaaMD59falseAnonymousREADTHUMBNAILVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.jpgVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.jpgGenerated Thumbnailimage/jpeg44221https://arca.fiocruz.br/bitstreams/ba968084-b51a-472a-ad31-b3f0d9b92d62/download856cccabda184bc2c845b2b48f403e58MD510falseAnonymousREADicict/454852025-12-10 15:45:46.672open.accessoai:arca.fiocruz.br:icict/45485https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T18:45:46Repositório Institucional da FIOCRUZ (ARCA) - 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