Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging

In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a...

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Bibliographic Details
Authors: Soares, Guilherme A. [UNESP], Prospero, Andre G. [UNESP], Calabresi, Marcos F. [UNESP], Rodrigues, Diego S., Simoes, Luis G. [UNESP], Quini, Caio C. [UNESP], Matos, Ronaldo R. [UNESP], Pinto, Leonardo A. [UNESP], Sousa-Junior, Ailton A., Bakuzis, Andris F., Mancera, Paulo A. [UNESP], Miranda, Jose R. A. [UNESP]
Format: article
Status:Published version
Publication Date:2019
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:English
OAI Identifier:oai:repositorio.unesp.br:11449/189012
Online Access:http://dx.doi.org/10.1109/TNB.2019.2912073
http://hdl.handle.net/11449/189012
Access Level:Open access
Keyword:ac biosusceptometry
magnetic imaging
Magnetic nanoparticles
pharmacokinetic model
Description
Summary:In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP.

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