Associação entre aterosclerose e marcadores de lesão renal em afrodescendentes hipertensos de comunidades remanescentes de quilombo no norte do Maranhão
BACKGROUND: Atherosclerotic lesions are highly prevalent among afrodescendants leading to increased morbidity and mortality from cardiovascular events. Thus, the aim of this study was to investigate the association between atherosclerosis and kidney injury markers in hypertensive afrodescendants fro...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Federal do Maranhão (UFMA) |
| Repositorio: | Biblioteca Digital de Teses e Dissertações da UFMA |
| Idioma: | portugués |
| OAI Identifier: | oai:tede2:tede/580 |
| Acceso en línea: | http://tedebc.ufma.br:8080/jspui/handle/tede/580 |
| Access Level: | acceso abierto |
| Palabra clave: | Aterosclerose Taxa de Filtração Glomerular Albuminúria Hipertensão Arterial Sistêmica Afrodescendentes Atherosclerosis Glomerular filtration rate Albuminuria Hypertension Afrodescendants CIENCIAS DA SAUDE; MEDICINA |
| Sumario: | BACKGROUND: Atherosclerotic lesions are highly prevalent among afrodescendants leading to increased morbidity and mortality from cardiovascular events. Thus, the aim of this study was to investigate the association between atherosclerosis and kidney injury markers in hypertensive afrodescendants from quilombo remnants communities in northern of Maranhão. METHODS: Cross-sectional study that assessed hypertensive afrodescendants from PREVRENAL cohort underwent two different imaging methods for diagnosis of atherosclerosis disease: 1- Carotid doppler ultrasonography (doppler US) to assess the intima-media thickness (cIMT) and/or 2- Coronary computed tomography for determination calcium score (CCS). The kidney damage markers evaluated were 1- estimated glomerular filtration rate (eGFR) and; 2- albuminuria. Information about clinical, laboratory and imaging data were collected in PREVRENAL study database. To evaluate factors associated with the occurrence of coronary and carotid atherosclerosis was adjusted Poisson model with robust variance. The significance level was 5%. Statistical analysis was performed using Stata 12.0 software. RESULTS: Two hundred-six patients (mean age 61.32±12.44 years and 61.65% women) underwent carotid doppler US and 155 patients (mean age 61.42±12.42 years and 62.58% women) underwent coronary CT were included in the study. cIMT presented high in 59.22% individuals evaluated and 41.94% of patients had CCS> 0. In the multivariate regression model, age ≥60 years (PR 1.23, p-value = 0.001), ACR> 30mg/g (PR 1.18, p-value = 0.040) and eGFR/CKD-EPI <60mL/min using cystatin C (PR 1.25, p-value = 0.045) were independently associated with carotid atherosclerosis. The model for coronary calcification were associated with CCS: male gender (PR 1.53, p-value = 0.010), age ≥ 60 years (PR 1.78, p-value = 0.001), use of ASA (PR 1.67, p-value = 0.018) and smoking (PR 1.51, p-value = 0.011). CONCLUSION: The occurrence of atherosclerotic lesions was high in this group. Kidney injury markers were associated only with carotid lesions, whereas traditional factors for atherosclerotic disease were associated with coronary lesions. Thus, afrodescendants with similar clinical and epidemiological characteristics should be strictly monitored and treated to reduce the risk of cardiovascular events. |
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