Waterborne aripiprazole blunts the stress response in zebrafish

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet...

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Detalles Bibliográficos
Autores: Barcellos, Heloisa Helena de Alcantara, Kalichak, Fabiana, Rosa, João Gabriel Santos, Oliveira, Thiago Acosta, Koakoski, Gessi, Idalencio, Renan, Abreu, Murilo Sander de, Giacomini, Ana Cristina Vendrametto Varrone, Fagundes, Michele, Variani, Cristiane, Rossini, Mainara, Piato, Angelo Luis Stapassoli, Barcellos, Leonardo Jose Gil
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/225520
Acceso en línea:http://hdl.handle.net/10183/225520
Access Level:acceso abierto
Palabra clave:Aripiprazol
Águas residuais
Peixe-zebra
Environmental impact
Stress and resilience
Descripción
Sumario:Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.

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