Frequency of Class I Anti HLA Alloantibodies in Patients Infected by HIV 1
The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The pres...
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | Brasil |
| Recursos: | Universidade Federal de Pelotas (UFPEL) |
| Repositorio: | Repositório Institucional da UFPel - Guaiaca |
| Idioma: | inglés |
| OAI Identifier: | oai:guaiaca.ufpel.edu.br:123456789/852 |
| Acesso em linha: | https://guaiaca.ufpel.edu.br/handle/123456789/852 |
| Access Level: | acceso abierto |
| Palavra-chave: | AIDS HIV HLA antigens Alloantibodies |
| Resumo: | The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The presence of class I anti-HLA alloantibodies and HLA allele’s were determined. Clinical evolution was set as fast (<1 year between diagnostic and death), moderate (1-3 years) or slow (>3 years). Class I anti-HLA alloantibodies presence was lower in healthy individuals than in those infected by HIV-1 (4.2% against 32.4%). However, an equal distribution of these alloantibodies was found among the individuals infected, independent on the clinical evolution. Thus, class I anti-HLA alloantibodies was not a determinant factor for patient worsening. |
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